Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Other Unique Bacteria

Other Unique Bacteria

Magnetic bacteria exhibit a directed movement called magnetotaxis, driven by structures called magnetosomes. These magnetosomes consist of chains of magnetic particles made of either magnetite (Fe₃O₄) or greigite (Fe₃S₄) and are organized in a linear conformation by a protein scaffold within invaginations of the cell membrane. The bacteria align along the north–south magnetic field lines, much like a compass needle. They are typically microaerophilic or anaerobic...

Second Uniqueness Theorem

Second Uniqueness Theorem

Consider a region consisting of several individual conductors with a definite charge density in the region between these conductors. The second uniqueness theorem states that if the total charge on each conductor and the charge density in the in-between region are known, then the electric field can be uniquely determined.
In contrast, consider that the electric field is non-unique and apply Gauss's law in divergence form in the region between the conductors and the integral form to the surface...

Biodiversity and Human Values

Biodiversity and Human Values

Human civilization relies on biodiversity in many ways. Sudden changes in species biodiversity result in environmental changes that can modify weather patterns and therefore human civilizations.

Human Genetics

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...

Cell Specific Gene Expression

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...

Requirements for Human Life

Requirements for Human Life

The Earth and its atmosphere have provided humans with air, water, and food, but these are not the only requirements for survival. Humans also require a specific range of temperature and pressure that the Earth and its atmosphere provides.
Oxygen
Atmospheric air is only about 20 percent oxygen, but that oxygen is a key component of the chemical reactions that keep the body alive, including the reactions that produce ATP. Brain cells are susceptible to a lack of oxygen because they require a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

CAFE: Cross-View Adaptive Fusion and Cluster Center Enhancement for Robust Multi-View Clustering.

IEEE transactions on pattern analysis and machine intelligence·2026

Same author

Engineering a TACI×CD3 Bispecific Antibody to Redirect T Cells Against Multiple Myeloma.

Blood advances·2026

Same author

Learning fair graph representation through graph information disentanglement.

Neural networks : the official journal of the International Neural Network Society·2026

Same author

The C9orf72/SMCR8 complex maintains microglial homeostasis via RAB8A-ESCRT-mediated lysosomal repair.

The EMBO journal·2026

Same author

Integrating multiple models to reveal the future trajectory and drivers of terrestrial carbon storage in the yellow river basin (Shandong section).

Environmental research·2026

Same author

Case Report: splenic abscess as a rare complication of perforated splenic flexure colorectal carcinoma: the role of imaging and multidisciplinary management.

Frontiers in oncology·2026

Same journal

NCR1 and NCR3 Expression and Genetic Polymorphism are Associated with CMV Infection after Allogeneic Haematopoietic Stem Cell Transplantation.

Archivum immunologiae et therapiae experimentalis·2026

Same journal

USP25 Promotes Glycolysis of Acute Myeloid Leukemia Cells and Enhances Tumor Immunity.

Archivum immunologiae et therapiae experimentalis·2026

Same journal

sEV-Enriched Serum Preparations From Healthy Individuals Protect Against Acute Pancreatitis-Induced Intestinal Barrier Dysfunction Through miR-579-3p/ANXA3-Mediated Inhibition of NLRP3 Inflammasome Pyroptosis.

Archivum immunologiae et therapiae experimentalis·2026

Same journal

Herd-Trained Immunity: A Hidden Component of Population-Level Innate Immunity.

Archivum immunologiae et therapiae experimentalis·2026

Same journal

<i>Saccharomyces cerevisiae</i> β-Glucan Training Induces a Nonclassical PGE<sub>2</sub>-<sup>High</sup>/NO-<sup>Low</sup> Macrophage Phenotype in Response to <i>Pseudomonas aeruginosa</i> Exopolysaccharide.

Archivum immunologiae et therapiae experimentalis·2026

Same journal

Salvianolic Acid C Activates the AMPK Pathway to Inhibit Ferroptosis and Alleviate Cardiomyocyte Injury after Acute Myocardial Infarction.

Archivum immunologiae et therapiae experimentalis·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 14, 2026

A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System

A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System

Published on: August 30, 2019

Humanized Mice as Unique Tools for Human-Specific Studies.

Kylie Su Mei Yong^1,2, Zhisheng Her¹, Qingfeng Chen^3,4,5

¹Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Proteos, 61 Biopolis Drive, Singapore, 138673, Singapore.

Archivum Immunologiae Et Therapiae Experimentalis

|February 8, 2018

Summary

This summary is machine-generated.

Humanized mice, immunodeficient models with human systems, are crucial for understanding human diseases and testing new therapies. Ongoing advancements promise better drug development for conditions like cancer and infectious diseases.

Keywords:

Drug testing Human diseases Human specificity Humanized mice Precision therapy

More Related Videos

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance

Published on: July 22, 2011

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

Related Experiment Videos

Last Updated: Feb 14, 2026

A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System

A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System

Published on: August 30, 2019

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance

Published on: July 22, 2011

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

Area of Science:

Biomedical Research
Translational Medicine
Immunology

Background:

Precision therapy necessitates advanced models to study human-specific diseases.
Humanized mice, defined as immunodeficient mice engrafted with human biological systems, are central to this research.
Recent decades have seen significant improvements in developing these models.

Purpose of the Study:

To review the background and advancements in humanized mouse models.
To discuss diseases and human-specific therapeutics evaluated using these models.
To explore solutions for enhancing humanized mice for future clinical applications.

Main Methods:

Literature review of humanized mouse model development and applications.
Analysis of studies utilizing humanized mice for disease pathogenesis and therapeutic testing.
Synthesis of current research on humanized mouse models for infectious disease and cancer.

Main Results:

Humanized mice closely recapitulate human disease pathogenesis and drug mechanisms.
Numerous innovative humanized mouse models show promise for drug discovery.
These models are vital for testing novel therapeutics against complex human conditions.

Conclusions:

Humanized mice are indispensable tools in advancing precision medicine.
Continued development is key to maximizing their potential in clinical settings.
These models offer significant promise for treating and controlling diseases like cancer and infectious diseases.