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Plasma adrenomedullin level in children with obesity: relationship to left ventricular function

Kotb Abbass Metwalley1, Hekma Saad Farghaly2, Tahra Sherief3

  • 1Pediatric Endocrinology Unit, Department of Pediatrics, Faculty of Medicine, Assiut University, B.O, Assiut, 71111, Egypt. kotb72@gmail.com.

World Journal of Pediatrics : WJP
|February 8, 2018
PubMed

Insights

Elevated adrenomedullin (AM) levels in obese children correlate with cardiac hypertrophy and dysfunction. Measuring AM may help identify children at high risk for developing left ventricular hypertrophy.

Area of Science:

  • Pediatric Cardiology
  • Endocrinology
  • Biomarker Research

Background:

  • Obesity in children is linked to increased risk of abnormal cardiac structure and function.
  • Adrenomedullin (AM), a cytokine, is explored as a potential biomarker for cardiac hypertrophy in obese children.
  • Limited knowledge exists regarding AM's role in pediatric obesity-related cardiac changes.

Purpose of the Study:

  • To assess plasma AM levels in obese children.
  • To investigate the relationship between AM levels and left ventricular (LV) functions in this cohort.
  • To determine if AM can serve as a biomarker for LV hypertrophy in obese children.

Main Methods:

  • A cohort of 60 obese children and 60 non-obese controls were studied.
  • Measurements included blood pressure, lipid profile, glucose, insulin, HOMA-IR, and plasma AM.
  • Echocardiography was used to assess cardiac dimensions and LV functions.

Main Results:

  • Obese children exhibited higher blood pressure, insulin, HOMA-IR, and AM levels compared to controls.
  • Obese children showed signs of LV hypertrophy (increased LVMI) and diastolic dysfunction.
  • Plasma AM levels positively correlated with LVMI and mitral deceleration time in obese children with LV hypertrophy.

Conclusions:

  • Plasma AM levels are elevated in obese children, especially those with LV hypertrophy.
  • AM levels correlate with increased blood pressure and insulin resistance.
  • Plasma AM measurement can aid in identifying obese children at risk for LV hypertrophy and dysfunction.
Abstract

Keywords:
AdrenomedullinLeft ventricular functionObesity

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