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Interactions Between Bisphenol A Exposure and GSTP1 Polymorphisms in Childhood Asthma
Tien Jen Lin1,2,3, Wilfried J J Karmaus4, Mei Lien Chen5
1Department of Neurosurgery, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Allergy, Asthma & Immunology Research
|February 8, 2018
Summary
Bisphenol A (BPA) exposure is linked to asthma. Specific genetic variants, like GSTP1, may influence this risk by affecting how the body processes BPA, potentially increasing asthma odds in children.
Area of Science:
- Environmental Health
- Genetics
- Respiratory Medicine
Background:
- Bisphenol A (BPA) is an environmental chemical with potential links to asthma development.
- Oxidative stress-related genes, including glutathione S-transferases (GSTM1, GSTP1), are implicated in BPA metabolism and response.
- Understanding gene-environment interactions is crucial for identifying individuals at higher risk for BPA-related health outcomes.
Purpose of the Study:
- To investigate if genetic variations in oxidative stress genes modulate the association between Bisphenol A (BPA) exposure and asthma risk.
- To determine the relationship between urinary BPA metabolite levels and asthma in children.
- To examine the interaction between specific gene polymorphisms (GSTM1, GSTP1) and BPA exposure in relation to asthma.
Main Methods:
- A case-control study involving 126 asthmatic children and 327 controls.
- Measurement of urinary Bisphenol A glucuronide (BPAG) levels using ultra-performance liquid chromatography/tandem mass spectrometry.
- Genotyping of oxidative stress-related genes (GSTM1, GSTP1) using TaqMan assays and statistical analysis including logistic regression.
Main Results:
- Elevated urinary BPAG levels were significantly associated with increased asthma risk (aOR=1.29).
- The GSTP1 AA genotype showed higher urine BPAG concentrations compared to the GG genotype.
- In children with high BPAG levels, the GSTP1 AA genotype was linked to a substantially higher odds of asthma (aOR=4.84).
Conclusions:
- Genetic variants in GSTP1 are associated with urinary BPA metabolite levels.
- Oxidative stress genes, specifically GSTP1, may act as modulators in the relationship between BPA exposure and asthma development.
- These findings highlight the role of gene-environment interactions in asthma etiology.
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