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Updated: Feb 14, 2026

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis
Published on: October 24, 2015
Undifferentiated thymic carcinoma with intracranial metastasis in a two-year-old
Nuthan Kumar1, Narendra Chaudhary1, Anne Jennifer Prabhu2
11 Department of Pediatrics, 30025 Christian Medical College and Hospital , Vellore, Tamil Nadu, India.
Abstract:
Thymic carcinoma with central nervous system involvement is very rare in children. A 27-month-old girl presented with a unilateral squint, vomiting, and behavioral changes. Imaging studies showed a silent anterior mediastinal mass and a large metastatic mass at the base of the skull. Biopsy of the anterior mediastinal mass confirmed an undifferentiated tumor consistent with thymic carcinoma. The child died within 3 months of the onset of symptoms, due to progression of the disease. These lethal tumors of unknown histogeneses and etiology are aggressive in nature, resistant to therapy, and have a rapidly fatal course.
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