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Association between the oxidative status, Vitamin D levels and respiratory function in asthmatic children

M Igde1, P Baran2, B G Oksuz3

  • 1Department of Pediatric Allergy and Immunology, Samsun Training and Research Hospital, Samsun, Turkey.

Nigerian Journal of Clinical Practice
|February 8, 2018
PubMed

Insights

Oxidative stress in children with asthma is linked to vitamin D levels. Further research is needed to see if vitamin D supplements can improve asthma control and reduce oxidative stress.

Area of Science:

  • Pediatric Pulmonology
  • Biochemistry
  • Nutritional Science

Background:

  • Asthma is a chronic respiratory condition in children.
  • Oxidative stress and vitamin D deficiency are implicated in asthma pathogenesis.
  • Understanding the interplay between oxidative markers, vitamin D, and lung function is crucial for asthma management.

Purpose of the Study:

  • To investigate the relationship between plasma concentrations of oxidative system markers, vitamin D, and respiratory functions in children with asthma.

Main Methods:

  • Serum concentrations of total antioxidant capacity (TAC), total oxidative status (TOS), paraoxonase-1 activity (PON-1), and 25-hydroxyvitamin D3 were measured in 91 children (aged 6-17) with stable asthma.
  • Respiratory functions including FEV1 and PEF were assessed.
  • Statistical correlation and multiple regression analyses were performed.

Main Results:

  • A significant positive correlation was observed between TAC and 25(OH)D3 (P = 0.021), TAC and TOS (P = 0.007), TAC and PON-1 (P = 0.028), and TAC and IgE (P = 0.033).
  • An inverse correlation was found between TAC and PEF (P = 0.024).
  • 25(OH)D3, TOS, and OSI index were independently related to TAC in regression analysis.

Conclusions:

  • Oxidative stress markers are correlated with serum vitamin D concentrations in children with asthma.
  • These findings suggest a potential role for vitamin D in modulating oxidative stress in pediatric asthma.
  • Clinical trials are warranted to determine if vitamin D supplementation can improve asthma control and reduce oxidative stress markers.
Abstract

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