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[Pathogenesis of chronic disorders of cerebral circulation]

P R Kamchatnov1, A V Chugunov1, A A Tyazhelnikov2

  • 1Pirogov Russian National Research Medical University, Moscow, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|February 8, 2018
PubMed

Insights

Chronic cerebrovascular disorders involve artery changes and impaired blood flow regulation. Nicergoline is being considered as a potential treatment to improve cerebral blood flow and autoregulation in affected patients.

Area of Science:

  • Neurology
  • Vascular Medicine
  • Pharmacology

Background:

  • Chronic disorders of cerebral circulation (CRMC) are prevalent conditions.
  • Pathogenesis involves structural/functional changes in cerebral arteries and impaired autoregulation.
  • Systemic arterial pressure also plays a crucial role.

Purpose of the Study:

  • To evaluate the potential of nicergoline (Sermion) in treating patients with CRMC.
  • To explore therapeutic options for improving cerebral blood flow and autoregulation.

Main Methods:

  • Literature review on CRMC pathogenesis and treatments.
  • Analysis of pharmacological properties of nicergoline.
  • Consideration of clinical application in CRMC patients.

Main Results:

  • Nicergoline is a drug that can increase cerebral blood flow.
  • It has the potential to restore autoregulation of cerebral circulation.
  • Its use is considered for patients suffering from CRMC.

Conclusions:

  • Nicergoline shows promise as a therapeutic agent for CRMC.
  • Further investigation into its efficacy and safety in CRMC patients is warranted.
  • Improving cerebral blood flow and autoregulation is key in managing these disorders.

Keywords:
autoregulation of cerebral circulationchronic cerebral ischemiamicroangiopathynicergolinesermion

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