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[Melatonin and hypertension: a possible role in combination therapy]
A V Budnevsky1, E S Ovsyannikov1, N V Rezova1
1N.N. Burdenko Voronezh State Medical University, Ministry of Health of Russia, Voronezh, Russia.
This review examines how natural melatonin levels and supplemental melatonin affect blood pressure. It focuses on nighttime blood pressure changes and the impact of different melatonin formulations.
Area of Science:
- Endocrinology
- Cardiovascular Medicine
- Pharmacology
Background:
- Melatonin, a hormone regulating sleep-wake cycles, has potential cardiovascular implications.
- Blood pressure regulation involves complex hormonal and neural mechanisms.
- Disruptions in melatonin production or administration may influence blood pressure.
Purpose of the Study:
- To review clinical trials on endogenous melatonin and blood pressure.
- To analyze the effects of exogenous melatonin on blood pressure, especially nocturnal BP.
- To investigate the influence of rapid-release vs. controlled-release melatonin formulations on BP.
Main Methods:
- Systematic literature review of clinical trials.
- Analysis of studies correlating endogenous melatonin levels with blood pressure.
- Evaluation of studies administering exogenous melatonin and measuring blood pressure response.
Main Results:
- Evidence suggests a complex relationship between endogenous melatonin and blood pressure.
- Exogenous melatonin, particularly controlled-release formulations, may lower nocturnal blood pressure.
- Rapid-release melatonin showed less consistent effects on blood pressure.
Conclusions:
- Melatonin's role in blood pressure regulation warrants further investigation.
- Controlled-release melatonin formulations appear more promising for managing nocturnal blood pressure.
- Individual responses to melatonin supplementation can vary.
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