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[A fixed-dose lisinopril+amlodipine+rosuvastatin combination: prospects for its use in patients with hypertension and

V I Podzolkov1, A E Bragina1, K K Osadchiy1

  • 1I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.

Terapevticheskii Arkhiv
|February 8, 2018
PubMed

Insights

In Russia, hypertension management is challenging, with low target blood pressure (BP) achievement. A triple combination therapy of lisinopril, amlodipine, and rosuvastatin shows promise for improving outcomes in hypertensive patients with dyslipidemia.

Area of Science:

  • Cardiology
  • Pharmacology
  • Public Health

Background:

  • Hypertension management in Russia shows low target blood pressure (BP) achievement rates: 14.4% in men and 30.9% in women.
  • A significant need for combination therapy exists (70.7%), with dyslipidemia prevalent in 60.7% of hypertensive patients.
  • Current statin use in Russian patients with coronary heart disease is low (9.7%), indicating poor lipid level control.

Purpose of the Study:

  • To evaluate the evidence-based medicine rationale for using a triple fixed-dose combination of lisinopril, amlodipine, and rosuvastatin.
  • To assess the potential benefits of this triple combination in managing hypertension and dyslipidemia concurrently.
  • To explore the role of this combination in organ protection and cardiovascular event risk reduction.

Main Methods:

  • Literature review of evidence-based medicine data.
  • Analysis of studies on combined antihypertensive therapy.
  • Examination of data regarding the efficacy and tolerability of fixed-dose combinations.
  • Review of research on the impact of lisinopril, amlodipine, and rosuvastatin on cardiovascular health.

Main Results:

  • Combined antihypertensive therapy, particularly fixed-dose combinations, offers higher efficiency and better tolerability.
  • The combination of an angiotensin-converting enzyme inhibitor (lisinopril) and a calcium antagonist (amlodipine) provides significant protective activity and metabolic neutrality.
  • Literature suggests that the triple combination of lisinopril + amlodipine + rosuvastatin holds high value for organ protection and reducing cardiovascular event risk.

Conclusions:

  • The triple fixed-dose combination of lisinopril, amlodipine, and rosuvastatin is a reasonable therapeutic strategy from an evidence-based medicine perspective.
  • This combination addresses both hypertension and dyslipidemia, common comorbidities in cardiovascular disease.
  • Improved patient compliance and better therapeutic outcomes are anticipated with fixed-dose combination therapies.

Keywords:
amlodipinecardiovascular riskfixed-dose combinationhypertensionlisinoprilorgan protectionrosuvastatin

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