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The Sesamum indicum Rhizosphere Associated Bacterium: A Source of Antifungal Compound

Renu Chaudhary1, Meenakshi Balhara1, Deepak Jangir1

  • 1Centre for Biotechnology, Maharshi Dayanand University, Rohtak-124001, Haryana, India.

Current Topics in Medicinal Chemistry
|February 8, 2018
PubMed
Abstract

Insights

Plant-associated bacteria from Sesamum indicum show potent antifungal activity against Aspergillus species. These findings highlight the potential of rhizosphere microbes as a source of novel antifungal compounds to combat increasing fungal infections.

Area of Science:

  • Microbiology
  • Mycology
  • Biotechnology

Background:

  • Fungal infections pose a growing threat to human health.
  • Current antifungal drugs have limitations, including reduced efficacy and adverse side effects.

Purpose of the Study:

  • To isolate and screen bacteria from Sesamum indicum rhizosphere for antifungal properties.
  • To evaluate the anti-Aspergillus activity of selected bacterial isolates.
  • To optimize conditions for enhanced antifungal compound production.

Main Methods:

  • Isolation and screening of bacterial cultures from Sesamum indicum rhizosphere.
  • Antifungal activity assays (co-culture, agar overlay) against Aspergillus species.
  • Biochemical characterization and 16S ribosomal RNA sequencing for bacterial identification.
  • Optimization of media and growth conditions.

Main Results:

  • Several bacterial isolates were obtained from Sesamum indicum rhizosphere.
  • Two potent strains, identified as Burkholderia sp. strain RC1 and Acinetobacter pittii strain RC2, demonstrated significant antifungal activity against Aspergillus fumigatus and Aspergillus niger.
  • Bacterial identification confirmed high similarity to known species via 16S rRNA sequencing.
  • Growth condition optimization influenced the production of anti-Aspergillus compounds.

Conclusions:

  • The plant rhizosphere is a valuable source of novel antifungal compounds.
  • Burkholderia sp. and Acinetobacter pittii strains show promise for developing new antifungal agents.
Keywords:
Anti-Aspergillus.AntifungalBacteriaInfectionPathogensRhizosphere

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