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Antibody Administration for Bone Tissue Engineering: A Systematic Review.

Sepanta Hosseinpour1, Maryam Rezai Rad2, Arash Khojasteh3,4

  • 1Students' Research Office, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Current Stem Cell Research & Therapy
|February 8, 2018
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Summary
This summary is machine-generated.

Antibodies show promise for bone regeneration, with local and systemic applications being studied. Further research in larger animals is needed before clinical use in bone tissue engineering.

Keywords:
Antibodybone defectsbone regenerationbone tissue engineeringgrowth factorscaffolds

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Immunology

Background:

  • Antibodies are increasingly used in medicine for diagnostics and therapeutics, including cancer and immune disorders.
  • Over 20 monoclonal antibodies are approved for various medical treatments.
  • Therapeutic antibodies have shown potential in bone tissue engineering applications.

Purpose of the Study:

  • To systematically review literature on antibody-assisted bone regeneration in animal models.
  • To analyze the efficacy of different antibody administration routes for bone repair.

Main Methods:

  • Conducted a systematic electronic literature search from January 1992 to June 2017.
  • Included English-language publications on antibody administration for bone regeneration.
  • Data extraction followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.

Main Results:

  • Analyzed 20 studies, with six including both in vitro and in vivo data.
  • Evaluated locally administered antibodies (e.g., anti-bone morphogenetic protein 2) and systemically administered antibodies (e.g., anti-sclerostin, anti-Dickkopf-1).
  • Data categorized by study type, cell types, animal models, defect characteristics, scaffolds, follow-up duration, and assessment outcomes.

Conclusions:

  • Antibody administration presents a novel and promising approach for bone tissue engineering.
  • Further research, especially in larger animal models, is necessary for potential clinical translation.
  • Antibody-based therapies could advance regenerative medicine for skeletal defects.