Related Experiment Video
Updated: Feb 14, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
Published on: November 3, 2011
[From sequence variability to structural and functional prediction: modeling of homologous protein families]
Pierre Barrat-Charlaix1, Martin Weigt1
1Sorbonne Universités, UPMC Université Paris 06, CNRS, Biologie Computationnelle et Quantitative, Institut de Biologie Paris Seine, 75005 Paris, France.
Abstract:
Thanks to next-generation sequencing, the number of sequenced genomes grows rapidly, providing in particular ample examples for the sequence variability between homologous proteins. This article discusses data-driven probabilistic sequence models, which are able to extract a multitude of information from sequence data alone, including (i) structural features like residue-residue contacts, which are formed in the folded protein, (ii) protein-protein interaction interfaces and (iii) phenotypic effects of amino-acid substitutions in proteins.
More Related Videos
Related Concept Videos
Protein Families
Protein Families
Gene Families
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
Structural Protein Function
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to...
Structural Protein Function
Protein and Protein Structure
A protein's shape is critical to its function. For example, an enzyme...

