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Related Experiment Videos

Allergic urticarial rash from oral codeine.

A C de Groot, J Conemans

    Contact Dermatitis
    |April 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    A patient developed a delayed-type allergic urticarial rash after taking oral codeine. This case highlights the importance of considering codeine allergy in drug eruptions and the role of patch testing.

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    Area of Science:

    • Pharmacology
    • Allergology
    • Dermatology

    Background:

    • Codeine, an opioid analgesic, is commonly prescribed for pain and cough relief.
    • Adverse drug reactions to codeine can manifest in various ways, including cutaneous manifestations.
    • Delayed-type hypersensitivity reactions are less commonly reported for codeine compared to immediate reactions.

    Observation:

    • A case report details a patient experiencing an urticarial rash.
    • The rash appeared as a delayed-type hypersensitivity reaction following oral administration of codeine.
    • This presentation suggests a specific allergic mechanism to the drug.

    Findings:

    • The case demonstrates a delayed-type allergy to orally administered codeine, presenting as urticaria.
    • Literature review indicates that contact allergy to codeine is a recognized phenomenon.

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  • Patch testing can be a valuable diagnostic tool for identifying drug-induced eruptions.

    • Implications:

    • This case underscores the need to consider codeine as a potential cause of delayed urticarial rashes.
    • The findings support the utility of patch testing in the diagnostic workup of suspected codeine hypersensitivity.
    • Further investigation into the immunologic mechanisms of codeine allergy may be warranted.