Related Experiment Video
Updated: Feb 14, 2026

Quantitation of Endothelial Cell Adhesiveness In Vitro
Published on: June 18, 2015
Effect on adhesion of a nanocapsules-loaded adhesive system
Bruna Genari1, Vicente Castelo Branco Leitune1, Denise Soledade Jornada2
1Universidade Federal do Rio Grande do Sul - UFRGS, School of Dentistry, Dental Materials Laboratory, Porto Alegre, RS, Brazil.
This study found that dental adhesives with up to 5% nanocapsules (NCs) containing indomethacin and triclosan, when used with a primer without NCs, maintained bond strength and conversion rates. This combination offers therapeutic benefits without compromising performance.
Area of Science:
- Materials Science
- Biomaterials Engineering
- Dental Materials Science
Background:
- Dental adhesives are crucial for restorative procedures.
- Incorporating therapeutic agents into adhesives can offer enhanced clinical benefits.
- Nanocapsules (NCs) provide a controlled release system for active compounds.
Purpose of the Study:
- To evaluate the effect of indomethacin- and triclosan-loaded nanocapsules (NCs) in dental primer and adhesive on degree of conversion, contact angle, and bond strength.
- To determine optimal concentrations of NCs for maintaining dental adhesive performance.
- To assess the potential of NC-loaded adhesives for combined bonding and therapeutic effects.
Main Methods:
- Incorporation of indomethacin- and triclosan-loaded NCs into primer (2%) and adhesive (1-10%).
- Evaluation of in situ degree of conversion (DC) using micro-Raman spectroscopy.
- Measurement of contact angle on dentin using optical tensiometry.
- Assessment of immediate and long-term micro-tensile bond strength (µTBS) after 1 year of water storage.
Main Results:
- Adhesives with NCs showed higher in situ DC (75.07–96.18%).
- NCs up to 5% in adhesive alone did not affect bond strength.
- Primer with NCs and higher adhesive NC concentrations reduced longitudinal µTBS.
- Primer without NCs and adhesive with up to 5% NCs maintained bond strength and DC.
Conclusions:
- Dental adhesives containing up to 5% indomethacin- and triclosan-loaded NCs, when used with a primer free of NCs, preserve immediate and long-term bond strength and degree of conversion.
- This formulation represents a viable strategy for developing dental adhesives with combined bonding efficacy and therapeutic anti-inflammatory/antibacterial properties.
- Further research may explore different NC concentrations and delivery systems for optimized therapeutic and mechanical outcomes.
Related Concept Videos
Adhesion
Capillary action is a result of water’s adhesive tendencies. When a narrow...
Cell Adhesion in Plants
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose,...
Immunoglobulin-like Cell Adhesion Molecules
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Intracellular Signaling Affects Focal Adhesions
Some...
Cell Adhesion Molecules - Types and Functions
CAM Families
The Integrin family of proteins is primarily involved...
Laminins are the Adhesive Proteins of Basal Lamina
In humans, the five forms of alpha chains are LAMA 1, LAMA 2, LAMA 3, LAMA 4, and LAMA 5. The four forms of beta chains are LAMB 1, LAMB 2, LAMB 3, and LAMB 4. The three forms of gamma...

