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Updated: Feb 14, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
Published on: August 18, 2020
Gender differences of cannabis smoking on serum leptin levels: population-based study
Fernanda P Moreira1, Carolina D Wiener1,2, Jacqueline F de Oliveira1
1Ciência Translacional em Transtornos Cerebrais, Departamento de Saúde e Comportamento, Centro de Ciências da Vida e da Saúde, Universidade Católica de Pelotas (UCPel), Pelotas, RS, Brazil.
Objective:
To evaluate the serum leptin levels in cannabis smokers.
Methods:
This was a cross-sectional population-based study of participants between the ages of 18 and 35 years. The data were collected through a self-administered questionnaire covering sociodemographic data and the use of psychoactive substances. Leptin levels were measured using a commercial ELISA kit.
Results:
Of the 911 participants, 6.7% were identified as cannabis smokers and had significantly lower leptin levels (p = 0.008). When stratified by gender, there was a significant decrease in leptin levels among male smokers (p = 0.039).
Conclusion:
Cannabis smoking was linked to leptin levels in men, suggesting that the response to biological signals may be different between men and women.
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