Related Experiment Video

Updated: Feb 14, 2026

Laparoscopic Anatomic S7+S8d Resection Preserving Inferior Right Hepatic Vein and S6 with Right Hepatic Vein Transection
06:00

Laparoscopic Anatomic S7+S8d Resection Preserving Inferior Right Hepatic Vein and S6 with Right Hepatic Vein Transection

Published on: December 30, 2025

352

Use of aspirin and bleeding-related complications after hepatic resection

M Gelli1, M A Allard1,2,3, O Farges4

  • 1Centre Hépato-Biliaire, Assistance Publique - Hôpitaux de Paris (AP-HP) Hôpital Paul-Brousse, Villejuif, France.

The British Journal of Surgery
|February 8, 2018
PubMed

Insights

This study found that continuing aspirin therapy during elective hepatectomy (liver surgery) did not increase bleeding risks. Patients on aspirin had similar outcomes to those not on the medication, suggesting it is safe for liver surgery.

Area of Science:

  • Hepatobiliary Surgery
  • Cardiovascular Pharmacology
  • Surgical Oncology

Background:

  • The safety of continuing antiplatelet therapy, specifically aspirin, during hepatectomy is not well-established.
  • Elective liver resections carry inherent risks, and the impact of perioperative aspirin use requires investigation.

Purpose of the Study:

  • To evaluate the operative risks associated with continuing aspirin therapy during elective hepatectomy.
  • To compare bleeding-related complications and other adverse events in patients undergoing liver surgery with or without aspirin.

Main Methods:

  • A multicentre prospective observational study compared patients undergoing elective hepatectomy with and without aspirin continuation.
  • Propensity score (PS) matching was employed to create balanced cohorts for analysis.
  • Outcomes assessed included severe hemorrhage (Dindo-Clavien grade IIIa or higher), transfusion rates, morbidity, complication scores, and mortality.

Main Results:

  • After PS matching, 108 patients were in each group (aspirin vs. control).
  • No significant differences were observed in severe hemorrhage (6.5% vs. 5.6%), intraoperative transfusion, overall hemorrhage, Comprehensive Complication Index (CCI) score, major complications, or 90-day mortality between the groups.
  • While major complications appeared higher in the aspirin group (23.1% vs. 13.9%), this did not reach statistical significance.

Conclusions:

  • Continuation of aspirin therapy does not appear to be associated with an increased risk of bleeding complications after elective hepatectomy.
  • This finding suggests that aspirin can be safely continued in patients undergoing elective liver surgery, provided other risk factors are managed.
Abstract

More Related Videos

Laparoscopic Anatomical Liver Segment VII Resection with Liver Parenchymal Transection Following a Priority Approach13:57

Laparoscopic Anatomical Liver Segment VII Resection with Liver Parenchymal Transection Following a Priority Approach

Published on: May 23, 2025

1.4K
Laparoscopic Anatomical Resection of the Right Anterior Lobe Based on the Laennec Capsule Technique06:11

Laparoscopic Anatomical Resection of the Right Anterior Lobe Based on the Laennec Capsule Technique

Published on: May 2, 2025

620

Related Concept Videos

Bleeding in Fresh Concrete01:22

Bleeding in Fresh Concrete

Bleeding in fresh concrete occurs when water from the mix rises to the surface. This happens because the mix's solid components fail to retain all the water as they settle, leading to separation where water collects at the top. The severity of bleeding can be measured by assessing the total settlement or by noting the decrease in height per unit height of concrete.
Bleeding can cause several issues in the concrete structure. Sometimes, the rising water gets trapped beneath large aggregate...
622
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
998
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
917
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.4K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
3.4K
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
281