Related Experiment Video
Updated: Feb 14, 2026

Asymmetrical Flow Field-Flow Fractionation for Sizing of Gold Nanoparticles in Suspension
Published on: September 11, 2020
Integration of Inverse Supercritical Fluid Extraction and Miniaturized Asymmetrical Flow Field-Flow Fractionation for
David Müller1,2, Margarida Nogueira1, Stefano Cattaneo1
1Centre Suisse d'Electronique et de Microtechnique (CSEM) , Bahnhofstrasse 1 , 7302 Landquart , Switzerland.
Abstract:
We report the use of inverse supercritical fluid extraction (SFE) and miniaturized asymmetrical flow field-flow fractionation (mAF4) for the preparation and subsequent analysis of titanium dioxide nanoparticles in model and commercial sunscreens. The approach allows for the fast and reliable fractionation and sizing of TiO2 nanoparticles and their quantitation in commercial products. This new method represents a powerful and efficient tool for the verification of nanoparticle content in a wide range of matrixes, as demanded by recently introduced regulatory requirements. Furthermore, the use of carbon dioxide as an environmentally friendly solvent is in line with the increasing need for ecologically compatible analytical techniques.
Related Concept Videos
Supercritical Fluid Chromatography
SFC utilizes a supercritical fluid mobile phase,...
Rapidly Varying Flow
Steady Flow of a Fluid Stream
During this process, the momentum of the fluid within the control volume remains constant over the time interval dt. By applying the...
Applications of Integration to Find Blood Flow
Inverse z-Transform by Partial Fraction Expansion
To begin the process, the poles of the function are identified and the function is...
Gene Flow

