Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ankle Joint01:10

Ankle Joint

3.1K
The ankle is formed by the talocrural joint (crural = leg). It consists of the articulations between the talus bone of the foot and the distal ends of the tibia and fibula of the leg. The superior aspect of the talus bone is square-shaped and has three areas of articulation. The top of the talus articulates with the inferior tibia. This is the portion of the ankle joint that carries the body weight between the leg and foot. The sides of the talus are firmly held in position by the articulations...
3.1K
Lateralization01:28

Lateralization

1.1K
Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.
1.1K
Cranial Bones: Lateral View01:27

Cranial Bones: Lateral View

7.3K
The lateral view of the cranium is dominated by temporal, sphenoid, and ethmoid bones.
The temporal bone forms the lower lateral side of the skull. The temporal bone is subdivided into several regions. The flattened upper portion is the squamous portion of the temporal bone. Below this area and projecting anteriorly is the zygomatic process of the temporal bone, which forms the posterior portion of the zygomatic arch. Posteriorly is the mastoid portion of the temporal bone. Projecting...
7.3K
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

6.6K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.6K
Self-Presentation: Self-Monitoring and Self-Handicapping02:05

Self-Presentation: Self-Monitoring and Self-Handicapping

44.8K
People can go to great lengths to protect their self-image and present themselves in ways that they want others to see them. Sociologist Erving Goffman presented the idea that a person is like an actor on a stage. Calling his theory dramaturgy, Goffman believed that we use “impression management” to present ourselves to others as we hope to be perceived. Each situation is a new scene, and individuals perform different roles depending on who is present (Goffman, 1959). Think about...
44.8K
Molecular Models02:00

Molecular Models

43.9K
Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
43.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

Development of a Pragmatic Prediction Model for Bone Stress Injuries in First-Year US Military Academy Cadets.

Journal of athletic training·2026
Same author

Effects of local muscle vibration on plantarflexor strength and activation in individuals with chronic ankle instability: a randomized crossover trial.

The Journal of sports medicine and physical fitness·2026
Same author

Epidemiology of Obesity During Pregnancy in Europe: A Systematic Review.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2026
Same author

Ankle joint contact forces and muscle contributions during walking differentiate chronic ankle instability from copers and uninjured controls.

Gait & posture·2026
Same author

Debt Burden and Impact on Physical Therapy Students.

Journal of allied health·2026
Same author

Impact of multiple levels of visual occlusion on static postural control.

Gait & posture·2026

Related Experiment Video

Updated: Feb 14, 2026

Treatment of Ankle Osteoarthritis with Total Ankle Replacement Through a Lateral Transfibular Approach
09:01

Treatment of Ankle Osteoarthritis with Total Ankle Replacement Through a Lateral Transfibular Approach

Published on: January 24, 2018

12.4K

Lateral Ankle Sprain in a Mouse Model: Lifelong Sensorimotor Dysfunction.

Erik A Wikstrom1, Tricia Hubbard-Turner2, Sophie Guderian3

  • 1Department of Exercise & Sport Science, University of North Carolina at Chapel Hill.

Journal of Athletic Training
|February 8, 2018
PubMed
Summary
This summary is machine-generated.

Ankle sprains in mice led to lifelong balance and movement problems, potentially indicating early posttraumatic osteoarthritis. These findings highlight the long-term impact of ankle injuries.

Keywords:
balancechronic ankle instabilitylocomotionmurine

More Related Videos

A Mouse Model of Ankle-Subtalar Complex Joint Instability
09:14

A Mouse Model of Ankle-Subtalar Complex Joint Instability

Published on: October 28, 2022

1.9K
Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease
10:32

Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease

Published on: June 17, 2013

56.4K

Related Experiment Videos

Last Updated: Feb 14, 2026

Treatment of Ankle Osteoarthritis with Total Ankle Replacement Through a Lateral Transfibular Approach
09:01

Treatment of Ankle Osteoarthritis with Total Ankle Replacement Through a Lateral Transfibular Approach

Published on: January 24, 2018

12.4K
A Mouse Model of Ankle-Subtalar Complex Joint Instability
09:14

A Mouse Model of Ankle-Subtalar Complex Joint Instability

Published on: October 28, 2022

1.9K
Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease
10:32

Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease

Published on: June 17, 2013

56.4K

Area of Science:

  • Orthopaedics
  • Biomechanics
  • Neuroscience

Background:

  • Ankle sprains are common sports injuries.
  • Chronic ankle instability (CAI) can lead to reduced quality of life and is linked to posttraumatic osteoarthritis.
  • Long-term studies are needed to confirm these links.

Purpose of the Study:

  • To investigate the long-term effects of mild and severe ankle sprains on balance and locomotion in a mouse model.
  • To quantify sensorimotor adaptations across the lifespan following ankle injury.

Main Methods:

  • A cohort study was conducted using a university research laboratory setting.
  • Fifty male mice were divided into control (SHAM), mild (MILD), and severe (SEVERE) ankle sprain groups.
  • Ankle sprains were induced surgically, and balance and gait were assessed for 78 weeks.

Main Results:

  • Ankle sprains exacerbated age-related declines in balance.
  • Foot slips were significantly higher in both MILD and SEVERE groups compared to SHAM.
  • The SEVERE group exhibited a shorter right-limb stride length compared to the SHAM group.

Conclusions:

  • Surgical transection of ankle ligaments in mice resulted in persistent sensorimotor dysfunction.
  • Observed declines starting at 42 weeks post-injury may indicate the development of posttraumatic osteoarthritis.
  • This study provides a lifespan perspective on the consequences of ankle sprains.