Related Experiment Video
Updated: Feb 14, 2026
Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy
Published on: January 12, 2019
Measurement of respiratory function decline in patients with Duchenne muscular dystrophy: a conjoint analysis
Elena Ripamonti1, Grazia D'Angelo2
1Elma Research s.r.l., Via Felice Casati 32, Milano, Italy.
Aim:
In Duchenne muscular dystrophy (DMD), little attention has been paid to severity of respiratory function decline (RFD) based on disease progression. We performed a conjoint analysis among 123 Italian clinicians to generate a scale for RFD in DMD patients.
Methods:
Before the interview, 11 attributes were selected by discussion among experts. 32 'patient profiles' were generated. Each physician assessed the severity of RFD for each profile. Each level/attribute was assigned an estimated usefulness to understand its impact on RFD.
Results:
The identified attributes were forced vital capacity, forced vital capacity decline, dysphagia, type of ventilation and peak cough flow. These results allowed the development of a scale for RFD severity.
Conclusion:
This scale can stratify DMD patients according to the severity of their RFD.
More Related Videos
05:54A Simple and Low-cost Assay for Measuring Ambulation in Mouse Models of Muscular Dystrophy
Published on: December 29, 2017
08:13Purification and Transplantation of Myogenic Progenitor Cell Derived Exosomes to Improve Cardiac Function in Duchenne Muscular Dystrophic Mice
Published on: April 10, 2019
Related Concept Videos
01:21Satellite Stem Cells and Muscular Dystrophy
01:18The Muscular System
01:19Magnetic Declination
01:27Physiology of Respiration I: Functions of the Respiratory System
Fundamental Processes in Respiration:
02:07Conservation of Declining Populations
01:31Anatomy of Respiratory System II: Lower Respiratory Tract
The Larynx
It is located between the pharynx and the trachea, acts as a passageway for air, and hosts several critical structures, such as the epiglottis, vocal cords, and glottis. The epiglottis acts as a gateway, guiding food to the...