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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Vaccine-associated hypersensitivity.

Michael M McNeil¹, Frank DeStefano¹

¹Immunization Safety Office, Centers for Disease Control and Prevention, Atlanta, Ga.

The Journal of Allergy and Clinical Immunology

|February 8, 2018

Summary

This summary is machine-generated.

Serious hypersensitivity reactions to vaccines are rare, but providers should monitor for anaphylaxis, especially with new influenza vaccine formulations. Further research is needed on vaccine adverse events.

Keywords:

Acute IgE mediated T cell mediated allergy anaphylaxis delayed hypersensitivity immunologically mediated mast cell postvaccination vaccine safety

Related Experiment Videos

Area of Science:

Immunology
Vaccinology
Public Health

Background:

Vaccine-associated hypersensitivity reactions, including anaphylaxis, are rare but can occur.
Influenza vaccines, with annual composition changes and new formulations, warrant specific attention due to widespread use.
Understanding hypersensitivity mechanisms is crucial for vaccine safety.

Purpose of the Study:

To review the occurrence and types of hypersensitivity reactions associated with vaccines.
To highlight the importance of monitoring adverse events, particularly anaphylaxis, after influenza vaccination.
To identify areas for future research regarding vaccine hypersensitivity.

Main Methods:

Literature review of vaccine-associated hypersensitivity reactions.
Analysis of reported systemic reactions, including anaphylaxis, post-vaccination.
Discussion of novel influenza vaccine types and their implications.

Main Results:

Serious systemic hypersensitivity reactions are rare, with anaphylaxis estimated at 1.31 per million doses.
Hypersensitivity can be triggered by vaccine antigens or other components.
New influenza vaccine types and recommendations for egg-allergic individuals require provider awareness.

Conclusions:

While severe vaccine reactions are uncommon, vigilance is necessary.
Further research is essential to understand pathophysiology, risk factors, and optimize vaccination schedules.
Adapting to new vaccine technologies and recommendations is key for public health.