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Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

Current insights in allergen immunotherapy.

Giovanni Passalacqua¹, Diego Bagnasco¹, Matteo Ferrando¹

¹Allergy and Respiratory Diseases, Policlinico San Martino, Department of Internal Medicine, University of Genoa, Genoa, Italy.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology

|February 8, 2018

Summary

This summary is machine-generated.

Allergen-specific immunotherapy (AIT) offers effective treatment for allergies and asthma, with new standardized options and promising advancements in food allergy desensitization and administration routes.

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Area of Science:

Immunology
Allergy Research
Pharmacology

Background:

Allergen-specific immunotherapy (AIT) is a proven treatment for respiratory and venom allergies.
Advances in understanding allergy mechanisms and diagnostics have improved AIT.
The application of AIT in asthma and novel approaches are growing.

Purpose of the Study:

To review recent advances and ongoing considerations in allergen-specific immunotherapy.
To highlight the impact of new product developments and diagnostic techniques on AIT.
To explore emerging trends and future directions in allergy treatment.

Main Methods:

Literature review of recent and clinically relevant studies.
Inclusion of data from PubMed and Scopus databases.
Focus on high-quality products and dose-finding trials.

Main Results:

Standardized AIT products, including new tablet forms, have improved treatment protocols.
Sublingual immunotherapy is effective for asthma, and oral/sublingual desensitization shows promise for food allergies.
Future AIT options include new administration routes, engineered allergens, and component-resolved diagnostics.

Conclusions:

AIT remains a valuable treatment, particularly with new standardized allergen tablets.
Food allergy treatment and novel administration routes are expanding the scope of AIT.
Component-resolved diagnostics will enable more precise AIT prescriptions.