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Subclinical atherosclerosis in adults with steady-state bronchiectasis: A case-control study
Yong-Hua Gao1, Shao-Xia Liu1, Juan-Juan Cui1
1Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Respiratory Medicine
|February 8, 2018
Summary
Bronchiectasis patients show impaired endothelial function, indicated by lower flow-mediated dilation (FMD). This dysfunction is linked to disease severity and risk factors, highlighting the need for early vascular screening in these patients.
Area of Science:
- Cardiovascular Medicine
- Respiratory Medicine
- Vascular Biology
Background:
- Bronchiectasis is linked to cardiovascular disease risks.
- Endothelial dysfunction may play a key role in this association.
- Subclinical atherosclerosis is a potential consequence of endothelial dysfunction.
Purpose of the Study:
- To investigate endothelial function in bronchiectasis patients.
- To measure flow-mediated dilation (FMD) and carotid intima-media thickness (CIMT).
- To identify risk factors impacting subclinical atherosclerosis in bronchiectasis.
Main Methods:
- 80 bronchiectasis patients and 80 healthy controls were studied.
- Endothelial function assessed via brachial artery FMD and CIMT.
- Disease severity evaluated using Bronchiectasis Severity Index and FACED scores.
Main Results:
- Bronchiectasis patients exhibited significantly lower FMD compared to controls (P < 0.001).
- FMD correlated negatively with Bronchiectasis Severity Index and FACED score.
- Age, BMI, Pseudomonas aeruginosa, and CT scores independently influenced FMD.
Conclusions:
- Bronchiectasis patients demonstrate increased risk of endothelial dysfunction.
- This dysfunction is independent of known risk factors.
- Early screening for vascular changes is crucial to mitigate cardiovascular event risks.
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