Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transcription01:10

Transcription

157.2K
Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
157.2K
Transcription01:17

Transcription

33.7K
Transcription is the synthesis of RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in correctly synthesizing messenger RNA (mRNA). Transcriptional regulation is responsible for the differentiation of different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...
33.7K
Transcription Factors02:16

Transcription Factors

82.9K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.9K
Eukaryotic Transcription Inhibitors01:52

Eukaryotic Transcription Inhibitors

11.1K
Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
Eukaryotic transcription inhibitors usually contain two distinct domains, a...
11.1K
Eukaryotic Transcription Activators02:42

Eukaryotic Transcription Activators

12.9K
Transcription activators are proteins that promote the transcription of genes from DNA to RNA. In most cases, these proteins contain two separate domains ‒ a domain that binds to DNA and a domain for activating transcription; however, in some cases, a single domain is responsible for both binding and activation of transcription, as seen in the glucocorticoid receptor and MyoD.
The binding domains are capable of recognizing and interacting with regulatory sequences on the DNA. These...
12.9K
Master Transcription Regulators02:23

Master Transcription Regulators

7.9K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The long noncoding RNA lnc13 restrains inflammatory responses to maintain oral tolerance to gluten.

Nature immunology·2026
Same author

Genetic determinants of childhood blood pressure and heart rate in relation to adult health outcomes: the consortium of childhood blood pressure.

European heart journal·2026
Same author

Regulatory elements in the Sox9 locus license the initiation of pancreatic ductal adenocarcinoma.

Cell reports·2026
Same author

Meta-analysis of genome-wide association studies of food allergy and IgE sensitization.

The Journal of allergy and clinical immunology·2026
Same author

m6A RNA methylation modulates antiviral response in celiac disease.

Genes and immunity·2026
Same author

Impact of Sample Type on ADAP-Based Autoantibody Detection for Type 1 Diabetes Population Screening.

Diabetes technology & therapeutics·2025

Related Experiment Video

Updated: Feb 14, 2026

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

3.4K

Profiling Celiac Disease-Related Transcriptional Changes.

Ainara Castellanos-Rubio1, Jose Ramon Bilbao1

  • 1University of the Basque Country (UPV/EHU), BioCruces Health Research Institute, Leioa, Basque Country, Spain.

International Review of Cell and Molecular Biology
|February 8, 2018
PubMed
Summary

Celiac disease (CD) involves complex genetics and gluten triggers an immune response. Transcriptome analyses reveal immune and pathway dysregulation in CD patients, highlighting areas for future research.

Keywords:
Association studyCeliac diseaseGene expressionSNPTranscriptomeeQTL

More Related Videos

Laser-assisted Microdissection LAM as a Tool for Transcriptional Profiling of Individual Cell Types
09:31

Laser-assisted Microdissection LAM as a Tool for Transcriptional Profiling of Individual Cell Types

Published on: May 10, 2016

9.8K
Single Cell Transcriptional Profiling of Adult Mouse Cardiomyocytes
08:23

Single Cell Transcriptional Profiling of Adult Mouse Cardiomyocytes

Published on: December 28, 2011

18.1K

Related Experiment Videos

Last Updated: Feb 14, 2026

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

3.4K
Laser-assisted Microdissection LAM as a Tool for Transcriptional Profiling of Individual Cell Types
09:31

Laser-assisted Microdissection LAM as a Tool for Transcriptional Profiling of Individual Cell Types

Published on: May 10, 2016

9.8K
Single Cell Transcriptional Profiling of Adult Mouse Cardiomyocytes
08:23

Single Cell Transcriptional Profiling of Adult Mouse Cardiomyocytes

Published on: December 28, 2011

18.1K

Area of Science:

  • Immunology
  • Genetics
  • Gastroenterology

Background:

  • Celiac disease (CD) is a chronic autoimmune disorder of the small intestine.
  • Genetic factors, particularly HLA-DQ2 and DQ8, play a significant role in CD susceptibility.
  • Gluten consumption triggers the disease by presenting gliadin peptides to T helper lymphocytes.

Purpose of the Study:

  • To investigate the functional role of genes associated with celiac disease pathogenesis.
  • To analyze transcriptome data from various tissues in celiac disease patients.
  • To explore the impact of genetic variations on gene expression and the noncoding genome in CD.

Main Methods:

  • Whole transcriptome analyses were performed on duodenal biopsies, gut epithelial cells, and peripheral blood.
  • Samples were obtained from diagnosed CD patients, treated patients on a gluten-free diet, and nonceliac controls.
  • Some experiments included in vitro gluten challenge with gliadin peptides.

Main Results:

  • Transcriptome analyses indicated an exacerbated immune response in celiac disease patients.
  • Dysregulation of signaling and cell cycle pathways was observed.
  • The impact of single nucleotide polymorphisms (SNPs) on gene expression is an emerging area of investigation.

Conclusions:

  • Transcriptome studies provide insights into the molecular mechanisms underlying celiac disease.
  • Further research is needed to elucidate the role of associated genes and the noncoding genome in CD pathogenesis.
  • Understanding these mechanisms can pave the way for novel therapeutic strategies.