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Updated: Feb 14, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

Structural heterogeneity and dynamics in protein evolution and design.

Kristoffer E Johansson¹, Kresten Lindorff-Larsen¹

¹The Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, DK-2200 Copenhagen, Denmark.

Current Opinion in Structural Biology

|February 8, 2018

Summary

This summary is machine-generated.

Protein design and laboratory evolution advance our understanding of protein dynamics. Incorporating conformational heterogeneity and dynamics is crucial for successful functional protein design.

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Evolution of Staircase Structures in Diffusive Convection

Evolution of Staircase Structures in Diffusive Convection

Published on: September 5, 2018

Area of Science:

Biochemistry
Structural Biology
Protein Engineering

Background:

Significant advancements in protein design allow for creating specific structures and functionalities.
Proteins are inherently dynamic, with dynamics playing a key role in their regulation and function.
Current protein design methods may not fully account for conformational heterogeneity and dynamics.

Purpose of the Study:

To compare protein design strategies with laboratory protein evolution.
To highlight the role of protein dynamics in both design and evolution.
To assess how conformational heterogeneity influences protein function and design.

Main Methods:

Review of recent studies in protein design and laboratory evolution.
Focus on experimental and computational approaches investigating protein dynamics.
Analysis of allosteric effects and interaction networks in evolved proteins.

Main Results:

Evolutionary trajectories demonstrably alter protein structural dynamics.
Allosteric effects are significantly pronounced in evolved proteins.
Coupling between structure and dynamics, mediated by interaction networks, facilitates functional adaptations.

Conclusions:

Explicit consideration of protein dynamics and conformational heterogeneity is vital for successful protein design.
Laboratory evolution provides insights into how dynamics are modulated for function.
Understanding the interplay of structure, dynamics, and networks is key to engineering novel protein functions.