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Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
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Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

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Long noncoding RNAs in cancer cells

Duc-Hiep Bach1, Sang Kook Lee1

  • 1College of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul, 151-742, South Korea.

Cancer Letters
|February 8, 2018
PubMed

Insights

Long noncoding RNAs (lncRNAs) are crucial regulators in human cancers, influencing biological processes by interacting with DNA, RNA, and proteins. Aberrant lncRNA expression offers potential for cancer diagnostics and therapeutics.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Long noncoding RNAs (lncRNAs) are increasingly recognized as critical regulators of biological processes.
  • They participate in various cellular mechanisms, acting as either tumor promoters or suppressors in malignancies.
  • Aberrant lncRNA expression is linked to multiple cancer phenotypes.

Purpose of the Study:

  • To elucidate the mechanisms of action of lncRNAs in cancer.
  • To detail their functional cellular roles and involvement in cancer progression.
  • To review recent advancements and future potential of lncRNAs in cancer diagnostics and therapeutics.

Main Methods:

  • Review of current literature on lncRNA functions in cancer.
  • Analysis of lncRNA interactions with macromolecules (DNA, RNA, protein).
  • Discussion of gene chip technology and bioinformatics in lncRNA detection.

Main Results:

  • lncRNAs modulate diverse biological processes in human cancers.
  • lncRNAs can function as either tumor promoters or tumor suppressors.
  • Abnormal lncRNA expression is detectable in various cancer types.

Conclusions:

  • lncRNAs play significant roles in cancer progression through various mechanisms.
  • lncRNAs hold promise as potential diagnostic markers for cancer.
  • lncRNAs represent a promising avenue for novel cancer therapeutics.
Keywords:
Cancer biomarkerDrug-resistanceHallmarks of cancerOncogenelncRNAs

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