Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

10.0K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.0K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.7K
3.7K
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

18.8K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
18.8K
piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

7.7K
PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
7.7K
Small interfering RNAs (siRNA)02:30

Small interfering RNAs (siRNA)

4.8K
4.8K
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

3.3K
Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Parkinson's disease as a multi-axis systems disorder: integrating molecular pathology and circuit-level therapeutics.

Cell communication and signaling : CCS·2026
Same author

CAR-T Cell Therapy: Manufacturing Platforms and Clinical Consequences.

Human gene therapy·2026
Same author

Editor's Note: Deguelin Analogue SH-1242 Inhibits Hsp90 Activity and Exerts Potent Anticancer Efficacy with Limited Neurotoxicity.

Cancer research·2026
Same author

Structural insights into selective recognition of ATP-mimicking inhibitors by the atypical kinase HASPIN.

Scientific reports·2026
Same author

Protection of skin from UVB-induced photoaging: Antioxidant and anti-inflammatory effects of avenanthramide C from oat sprout extract via suppression of MAPK pathways.

Journal of photochemistry and photobiology. B, Biology·2026
Same author

Extracellular Vesicles in Osteoarthritis: From Pathogenic Mediators to Engineered Therapeutics in a Precision Medicine Roadmap.

Journal of extracellular biology·2026

Related Experiment Video

Updated: Feb 14, 2026

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

9.4K

Long noncoding RNAs in cancer cells.

Duc-Hiep Bach1, Sang Kook Lee1

  • 1College of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul, 151-742, South Korea.

Cancer Letters
|February 8, 2018
PubMed
Summary

Long noncoding RNAs (lncRNAs) are crucial regulators in human cancers, influencing biological processes by interacting with DNA, RNA, and proteins. Aberrant lncRNA expression offers potential for cancer diagnostics and therapeutics.

Keywords:
Cancer biomarkerDrug-resistanceHallmarks of cancerOncogenelncRNAs

More Related Videos

Isolation of Small Noncoding RNAs from Human Serum
06:44

Isolation of Small Noncoding RNAs from Human Serum

Published on: June 19, 2014

18.6K
Author Spotlight: A Computational Pipeline for Analyzing Chimeric Noncoding RNA-Target RNA Interactions in High-Throughput Sequencing Data
07:35

Author Spotlight: A Computational Pipeline for Analyzing Chimeric Noncoding RNA-Target RNA Interactions in High-Throughput Sequencing Data

Published on: December 1, 2023

1.2K

Related Experiment Videos

Last Updated: Feb 14, 2026

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

9.4K
Isolation of Small Noncoding RNAs from Human Serum
06:44

Isolation of Small Noncoding RNAs from Human Serum

Published on: June 19, 2014

18.6K
Author Spotlight: A Computational Pipeline for Analyzing Chimeric Noncoding RNA-Target RNA Interactions in High-Throughput Sequencing Data
07:35

Author Spotlight: A Computational Pipeline for Analyzing Chimeric Noncoding RNA-Target RNA Interactions in High-Throughput Sequencing Data

Published on: December 1, 2023

1.2K

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Long noncoding RNAs (lncRNAs) are increasingly recognized as critical regulators of biological processes.
  • They participate in various cellular mechanisms, acting as either tumor promoters or suppressors in malignancies.
  • Aberrant lncRNA expression is linked to multiple cancer phenotypes.

Purpose of the Study:

  • To elucidate the mechanisms of action of lncRNAs in cancer.
  • To detail their functional cellular roles and involvement in cancer progression.
  • To review recent advancements and future potential of lncRNAs in cancer diagnostics and therapeutics.

Main Methods:

  • Review of current literature on lncRNA functions in cancer.
  • Analysis of lncRNA interactions with macromolecules (DNA, RNA, protein).
  • Discussion of gene chip technology and bioinformatics in lncRNA detection.

Main Results:

  • lncRNAs modulate diverse biological processes in human cancers.
  • lncRNAs can function as either tumor promoters or tumor suppressors.
  • Abnormal lncRNA expression is detectable in various cancer types.

Conclusions:

  • lncRNAs play significant roles in cancer progression through various mechanisms.
  • lncRNAs hold promise as potential diagnostic markers for cancer.
  • lncRNAs represent a promising avenue for novel cancer therapeutics.