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Related Experiment Video

Updated: Feb 14, 2026

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice

Published on: May 10, 2019

Contact heat evoked potentials: Reliable acquisition from lower extremities.

J Rosner¹, M Hubli¹, P Hostettler¹

¹Spinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology

|February 8, 2018

Summary

Increasing baseline temperature improves contact heat evoked potentials (CHEPs) acquisition in lower extremities. This method enhances the reliability of CHEPs for assessing small fiber integrity.

Keywords:

A-delta fibers Contact heat evoked potentials Lower extremities Small fiber integrity Test-retest reliability

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Area of Science:

Neuroscience
Clinical Electrophysiology

Background:

Contact Heat Evoked Potentials (CHEPs) are used to assess small fiber neuropathy.
Reliability of CHEPs in lower extremities requires further investigation.

Purpose of the Study:

To evaluate the test-retest reliability of CHEPs in the lower extremities.
To compare two stimulation protocols: normal and increased baseline temperature.

Main Methods:

32 healthy subjects participated, with 22 retested.
CHEPs were recorded from L2, L5, and S2 dermatomes.
Test-retest reliability was analyzed using different stimulation protocols.

Main Results:

Increased baseline temperature improved CHEPs acquisition, especially at distal sites (L5, S2).
CHEP latency (N2 potential) showed the highest reliability.
CHEP amplitudes demonstrated fair to excellent reliability.

Conclusions:

Increasing thermode baseline temperature enhances CHEPs acquisition from lower extremities.
CHEPs are a reliable diagnostic tool for evaluating small fiber integrity.