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Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation

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Towards a complete structural deciphering of Type VI secretion system.

Van Son Nguyen¹, Badreddine Douzi¹, Eric Durand²

¹Architecture et Fonction des Macromolécules Biologiques, Aix-Marseille Université, Campus de Luminy, Case 932, 13288 Marseille Cedex 09, France; Architecture et Fonction des Macromolécules Biologiques, Centre National de la Recherche Scientifique (CNRS), Campus de Luminy, Case 932, 13288 Marseille Cedex 09, France.

Current Opinion in Structural Biology

|February 8, 2018

Summary

This summary is machine-generated.

The Type VI secretion system (T6SS) is a bacterial nanomachine that injects toxins. Future studies should focus on the baseplate structure for a complete understanding of T6SS assembly and function.

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Area of Science:

Microbiology
Structural Biology
Bacteriology

Background:

The Type VI secretion system (T6SS) is a complex nanomachine found in Gram-negative bacteria.
T6SS utilizes a contractile mechanism to deliver effector proteins into target cells, impacting bacterial interactions.
Key components include the trans-membrane complex (TMC), baseplate, and tail.

Purpose of the Study:

To review the current structural understanding of the T6SS.
To highlight the need for further structural characterization of the T6SS baseplate.
To propose future research directions for a complete T6SS structural description.

Main Methods:

Cryo electron microscopy (cryoEM) for tail structure elucidation.
X-ray crystallography and Electron Microscopy (EM) for trans-membrane complex structure determination.
Cryo-tomography proposed for low/medium resolution mapping.

Main Results:

Recent cryoEM studies have resolved the T6SS tail structure in different conformations.
The structure of the trans-membrane complex (TMC) has been determined.
The structural characterization of the T6SS baseplate remains incomplete.

Conclusions:

Significant progress has been made in elucidating T6SS component structures.
The T6SS baseplate is a critical area for future structural investigation.
Integrating structural data via cryo-tomography is essential for a holistic T6SS model.