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Updated: Feb 14, 2026

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Enzymatic amidation for industrial applications
Brent M Dorr1, Douglas E Fuerst1
1Advanced Manufacturing Technologies, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, United States.
Abstract:
Nature has developed a robust toolbox for the formation of amide bonds, enabling a variety of disconnections applicable to small molecule synthesis. In spite of this, the exploitation of biocatalytic techniques for industrial synthesis remains limited to a few very important cases. This review discusses previously demonstrated techniques for the biocatalytic synthesis of amide bonds, reviews examples of industrial scale-up of these techniques, and identifies a number of limitations to the scalability within the current state of the art.
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