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On vasodilators, magnesium and second messengers.

G A Charbon

    Journal Des Maladies Vasculaires
    |January 1, 1986
    PubMed
    Summary

    Magnesium ions and potentially potassium ions act as vasodilators by reducing vascular resistance uniformly across all vascular beds. This suggests they may function as second messengers, unlike peptide hormones and biogenic amines.

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    Area of Science:

    • Cardiovascular Physiology
    • Pharmacology

    Background:

    • Peptide hormones and biogenic amines exhibit specific vascular response patterns.
    • Arteriolar walls show homogeneous morphology throughout the body.

    Purpose of the Study:

    • To investigate the vasodilating mechanisms of various compounds.
    • To compare the vascular effects of magnesium ions with peptide hormones and biogenic amines.

    Main Methods:

    • Hemodynamic studies in anesthetized dogs.
    • Multichannel electromagnetic flowmetry at the organ level.

    Main Results:

    • Peptide hormones and biogenic amines displayed unique "maps" of vascular responses.
    • Magnesium ions reduced vascular resistance uniformly across all vascular areas.
    • Magnesium ions demonstrated similar time-frame and dose-dependency without altering cardiac output or perfusion.

    Conclusions:

    • The homogeneous vascular effects of magnesium ions contrast with the specific actions of hormones and amines.
    • A hypothesis suggests hormones and amines induce vasodilation via metabolite release acting as second messengers.
    • Magnesium and possibly potassium ions meet the criteria for potential second messenger vasodilators.

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