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Functional-morphological studies on in vitro cardionatrin release.

A J de Bold, M L de Bold, I R Sarda

    Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension
    |June 1, 1986
    PubMed
    Summary
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    Heart atrial cardiocytes produce atrial natriuretic peptides (ANP) to regulate the renin-angiotensin-aldosterone system. Increased mechanical load on rat atria directly stimulates ANP release, indicating intrinsic stretch-secretion coupling.

    Area of Science:

    • Cardiology
    • Endocrinology
    • Physiology

    Background:

    • Atrial natriuretic peptides (ANP) are cardiac hormones modulating the renin-angiotensin-aldosterone system.
    • In rats, ANP is stored as cardionatrin IV and processed to cardionatrin I before release from atrial cardiocytes.

    Purpose of the Study:

    • To investigate the relationship between mechanical load and ANP release from atrial cardiocytes.
    • To explore the intrinsic mechanisms of ANP secretion in response to atrial stretch.

    Main Methods:

    • Development of an isolated perifused rat atria preparation.
    • Quantitative and qualitative analysis of ANP release under varying mechanical loads.

    Main Results:

    • Increased mechanical load on the isolated atria preparation resulted in a higher rate of immunoreactive cardionatrin release.

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  • Demonstrated a direct correlation between atrial stretch and ANP secretion.

    • Conclusions:

    • The atria possess an intrinsic 'stretch-secretion coupling' mechanism for ANP release.
    • Mechanical forces play a crucial role in regulating the secretion of atrial natriuretic peptides.