IL-13 -1112 polymorphism and periodontitis susceptibility: a meta-analysis

Area of Science:

• Genetics
• Immunology
• Periodontology

Background:

• Conflicting findings exist regarding the association between the IL-13 -1112C/T polymorphism and periodontitis risk.
• Previous studies have yielded inconsistent conclusions on this genetic link.

Purpose of the Study:

• To investigate the association between the IL-13 -1112C/T polymorphism and susceptibility to periodontitis.
• To clarify the role of this specific IL-13 gene variant in the development of periodontal disease.

Main Methods:

• A meta-analysis was conducted using studies from multiple electronic databases (PubMed, Embase, Cochrane Library, CNKI, Wanfang) up to November 30, 2016.
• Case-control studies examining the IL-13 -1112 polymorphism and periodontitis were selected, with data analyzed using STATA 12.0.
• Study quality was assessed using the Newcastle-Ottawa scale, and odds ratios with 95% confidence intervals were calculated.

Main Results:

• The meta-analysis included 5 case-control studies (710 cases, 671 controls).
• Significant associations were found for CC vs TT, CT vs TT, and TT vs CT+CC models of the IL-13 -1112 polymorphism in relation to periodontitis susceptibility.
• Subgroup analysis revealed significant associations in chronic periodontitis but not in aggressive periodontitis.

Conclusions:

• The IL-13 -1112 polymorphism may be associated with periodontitis susceptibility, particularly chronic periodontitis.
• No significant association was observed between the IL-13 -1112 polymorphism and aggressive periodontitis.
• Further large-scale, multi-ethnic case-control studies are recommended to validate these findings.