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Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression
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Altered white matter microstructure in lupus patients: a diffusion tensor imaging study.

Jessika Nystedt1,2,3, Markus Nilsson4, Andreas Jönsen5

  • 1Department of Clinical Sciences Lund/Diagnostic Radiology, Lund University, Lund, Sweden. jessika.nystedt@med.lu.se.

Arthritis Research & Therapy
|February 9, 2018
PubMed
Summary
This summary is machine-generated.

Systemic lupus erythematosus (SLE) alters white matter microstructure, particularly in relation to disease duration and fatigue. These brain changes occur in SLE patients, irrespective of neuropsychiatric symptoms, indicating broader cerebral involvement.

Keywords:
Cognitive impairmentDiffusion tensor imagingMagnetic resonance imagingNeuropsychiatric systemic lupus erythematosusSystemic lupus erythematosusWhite matter microstructure

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Area of Science:

  • Neuroimaging
  • Rheumatology
  • Neurology

Background:

  • Systemic lupus erythematosus (SLE) is an autoimmune disease with potential neurological complications.
  • Neuropsychiatric symptoms (NPSLE) are a recognized manifestation, but subclinical white matter changes may occur in all SLE patients.

Purpose of the Study:

  • To investigate white matter microstructure alterations in SLE patients.
  • To determine if these alterations differ between patients with and without neuropsychiatric symptoms.

Main Methods:

  • Structural MRI and diffusion tensor imaging (DTI) were used in 64 female SLE patients and 21 healthy controls.
  • SLE patients were classified as neuropsychiatric SLE (NPSLE) or non-neuropsychiatric SLE (nonNPSLE).
  • Clinical, laboratory, cognitive, and self-assessment data were collected.

Main Results:

  • SLE patients showed reduced fractional anisotropy (FA) in the right rostral cingulum and corpus callosum.
  • Increased mean diffusivity (MD) was observed in the left hippocampal cingulum of SLE patients.
  • No significant differences in DTI parameters were found between NPSLE and nonNPSLE subgroups. Disease duration correlated with reduced FA.

Conclusions:

  • White matter microstructure is altered in SLE patients, linked to disease duration and fatigue.
  • Cerebral involvement in SLE extends beyond the NPSLE subgroup, suggesting widespread effects.