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Updated: Feb 14, 2026

An Ultrasonic Tool for Nerve Conduction Block in Diabetic Rat Models
Published on: October 20, 2017
Challenges associated with nerve conduction block using kilohertz electrical stimulation
Yogi A Patel1, Robert J Butera
1Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, United States of America. Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, United States of America.
Abstract:
Neuromodulation therapies, which electrically stimulate parts of the nervous system, have traditionally attempted to activate neurons or axons to restore function or alleviate disease symptoms. In stark contrast to this approach is inhibiting neural activity to relieve disease symptoms and/or restore homeostasis. One potential approach is kilohertz electrical stimulation (KES) of peripheral nerves-which enables a rapid, reversible, and localized block of conduction. This review highlights the existing scientific and clinical utility of KES and discusses the technical and physiological challenges that must be addressed for successful translation of KES nerve conduction block therapies.
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