Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Electrical Conductivity01:13

Electrical Conductivity

1.8K
In perfect conductors, the electric field inside is always zero due to the abundance of free electrons, which nullify any field by flowing. As a result, any residual charge resides on the surface.
In a practical conductor, an applied electric field may be sustained, causing a flow of electrons, which produce a current. The differential form of the current, the current density, is related to the electric field.
More generally, it is related to the force per unit charge, which involves the...
1.8K
Electric Field of Parallel Conducting Plates01:16

Electric Field of Parallel Conducting Plates

1.8K
Gauss' law relates the electric flux through a closed surface to the net charge enclosed by that surface. Gauss's law can be applied to find the electric field and the charge enclosed in a region depending on its charge distribution.
Consider a cross-section of a thin, infinite conducting plate having a positive charge. For such a large thin plate, as the thickness of the plate tends to zero, the positive charges lie on the plate's two large faces. Without an external electric field, the...
1.8K
Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia01:30

Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia

2.1K
Depending on the target organ, local anesthetics (LAs) can be administered via various routes. In surface anesthesia, LAs are applied directly to the surface of the skin or mucous membranes. It is widely used for topical skin numbing before venipuncture or minor surgical procedures. Commonly used surface local anesthetics are lidocaine or benzocaine sprays or creams. Surface anesthesia occurs within 5 minutes and lasts for about 60 minutes. One of the main disadvantages of topical anesthesia is...
2.1K
Conduct Disorder01:28

Conduct Disorder

622
Conduct disorder is a complex mental health diagnosis characterized by a repetitive and persistent pattern of behavior that violates societal norms, the rights of others, or age-appropriate rules. The diagnostic criteria for conduct disorder require the presence of at least three problematic behaviors within the past 12 months, with at least one occurring in the past six months. These behaviors are grouped into four categories: aggression toward people and animals; destruction of property;...
622
Conduction System of the Heart01:19

Conduction System of the Heart

13.7K
Autorhythmicity is a term that refers to the heart's inherent ability to generate electrical signals and instigate muscle contractions. This self-regulating conduction system within the heart consists of two key components: the pacemaker cells and specialized conducting cells.
The pacemaker cells are located in two primary nodes: the sinoatrial (SA) node and the atrioventricular (AV) node. The SA node pacemaker cells can autonomously depolarize, triggering an action potential that leads to the...
13.7K
Conduction System of the Heart01:20

Conduction System of the Heart

4.1K
The cardiac conduction system produces and transmits electrical impulses that prompt myocardial contraction, ensuring efficient heart function. This intricate system ensures that the heart beats in a coordinated and efficient manner, beginning with the atria and then the ventricles. The conduction system optimizes cardiac output by maintaining this precise sequence, which is crucial for adequate blood circulation.
This system relies on the unique properties of nodal and Purkinje cells:...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DeepLabCut increases markerless tracking efficiency in X-ray video analysis of rodent locomotion.

The Journal of experimental biology·2022
Same author

Environmental Enrichment Sharpens Sensory Acuity by Enhancing Information Coding in Barrel Cortex and Premotor Cortex.

eNeuro·2021
Same author

Core Competencies for Undergraduates in Bioengineering and Biomedical Engineering: Findings, Consequences, and Recommendations.

Annals of biomedical engineering·2020
Same author

Targeted Vagus Nerve Stimulation does not Disrupt Cardiac Function in the Diabetic Rat.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2020
Same author

Enteric Neuromodulation for the Gut and Beyond.

Cold Spring Harbor perspectives in medicine·2019
Same author

High-density EEG characterization of brain responses to auditory rhythmic stimuli during wakefulness and NREM sleep.

NeuroImage·2017
Same journal

A computational framework for fitting biophysical basal-ganglia network models, applied to Parkinsonian beta oscillations.

Journal of neural engineering·2026
Same journal

A sensor-driven Hill-type muscle modeling framework integrating sEMG and pFMG for biceps brachii force estimation.

Journal of neural engineering·2026
Same journal

Overcoming brain non-stationarity: Adaptive RLS classification for stable BCIs based on auditory evoked potentials.

Journal of neural engineering·2026
Same journal

Mapping neural representations of fine and gross upper-limb movements across dorsoventral subthalamic nucleus subregions in Parkinson's disease.

Journal of neural engineering·2026
Same journal

Ultra-flexible wireless endovascular stimulator for cortical simulation.

Journal of neural engineering·2026
Same journal

Influence of frequency and pulse train duration on respiratory responses during transcutaneous phrenic nerve stimulation in humans.

Journal of neural engineering·2026
See all related articles

Related Experiment Video

Updated: Feb 14, 2026

An Ultrasonic Tool for Nerve Conduction Block in Diabetic Rat Models
10:27

An Ultrasonic Tool for Nerve Conduction Block in Diabetic Rat Models

Published on: October 20, 2017

7.9K

Challenges associated with nerve conduction block using kilohertz electrical stimulation.

Yogi A Patel1, Robert J Butera

  • 1Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, United States of America. Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, United States of America.

Journal of Neural Engineering
|February 9, 2018
PubMed
Summary
This summary is machine-generated.

Kilohertz electrical stimulation (KES) offers a novel approach to neuromodulation by reversibly blocking nerve conduction. This method contrasts with traditional activation therapies and shows promise for treating various conditions.

More Related Videos

Assessment of Neuromuscular Function Using Percutaneous Electrical Nerve Stimulation
07:53

Assessment of Neuromuscular Function Using Percutaneous Electrical Nerve Stimulation

Published on: September 13, 2015

22.8K
Optogenetic Stimulation of the Auditory Nerve
10:53

Optogenetic Stimulation of the Auditory Nerve

Published on: October 8, 2014

15.1K

Related Experiment Videos

Last Updated: Feb 14, 2026

An Ultrasonic Tool for Nerve Conduction Block in Diabetic Rat Models
10:27

An Ultrasonic Tool for Nerve Conduction Block in Diabetic Rat Models

Published on: October 20, 2017

7.9K
Assessment of Neuromuscular Function Using Percutaneous Electrical Nerve Stimulation
07:53

Assessment of Neuromuscular Function Using Percutaneous Electrical Nerve Stimulation

Published on: September 13, 2015

22.8K
Optogenetic Stimulation of the Auditory Nerve
10:53

Optogenetic Stimulation of the Auditory Nerve

Published on: October 8, 2014

15.1K

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Neuromodulation

Background:

  • Traditional neuromodulation aims to activate neural pathways for functional restoration or symptom relief.
  • An alternative strategy involves inhibiting neural activity to manage diseases and restore homeostasis.
  • Peripheral nerve stimulation is a key area within neuromodulation research.

Purpose of the Study:

  • To review the scientific and clinical applications of kilohertz electrical stimulation (KES) for nerve conduction block.
  • To explore KES as a method for inhibiting neural activity.
  • To identify challenges in translating KES therapies into clinical practice.

Main Methods:

  • Review of existing scientific literature on kilohertz electrical stimulation.
  • Analysis of clinical studies and case reports utilizing KES.
  • Discussion of the technical and physiological principles of KES nerve conduction block.

Main Results:

  • Kilohertz electrical stimulation (KES) enables rapid, reversible, and localized blockade of nerve conduction.
  • KES presents a distinct approach to neuromodulation by inhibiting, rather than activating, neural pathways.
  • Evidence suggests potential utility in alleviating disease symptoms and restoring physiological balance.

Conclusions:

  • Kilohertz electrical stimulation (KES) is a promising neuromodulation technique for targeted nerve conduction block.
  • Further research and development are needed to overcome technical and physiological hurdles for widespread clinical adoption.
  • KES offers a novel therapeutic avenue distinct from conventional activation-based neuromodulation strategies.