Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Families02:47

Protein Families

17.2K
Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key...
17.2K
Protein Families02:47

Protein Families

4.5K
4.5K
Gene Families01:57

Gene Families

10.0K
Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
10.0K
Gene Families01:57

Gene Families

3.9K
3.9K
Family Therapy01:30

Family Therapy

620
Family therapy conceptualizes psychological challenges as arising from dysfunctional interactions within the family unit, rather than as isolated issues within individuals. This approach seeks to address and transform the patterns of communication, roles, and relationships within families to promote healthier dynamics and emotional well-being for all members.
Strategic Family Therapy
Strategic family therapy emphasizes resolving communication barriers and improving problem-solving abilities...
620
Sources of Self-Esteem I: Family Experience01:18

Sources of Self-Esteem I: Family Experience

197
Self-esteem, a crucial component of psychological development, is significantly shaped by familial experiences. The early parent-child relationship serves as a foundational influence on a child's self-concept, with long-lasting effects extending into adolescence and adulthood.Parental Behaviors and Early Self-Esteem FormationEmpirical studies have identified four principal parental behaviors that foster healthy self-esteem in children. These include expressions of acceptance, affection, and...
197

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Non-invasive urinary heteroplasmy screening outperforms blood testing for certain mitochondrial DNA variants in mitochondrial disease patients.

Molecular genetics and metabolism·2026
Same author

Nanopore-based haplotype-resolved X chromosome inactivation for severity assessment in X-linked disorders: An AIFM1 study with a mosaic PDHA1 carrier.

HGG advances·2026
Same author

Sex Differences in the Diagnosis and Treatment of Japanese Patients With Familial Hypercholesterolemia: A Retrospective Cohort Study.

Journal of lipid and atherosclerosis·2026
Same author

Quantification of glycosaminoglycans in dried blood spots, and evaluation of its usefulness as a secondary newborn screening test for mucopolysaccharidoses.

Biochemistry and biophysics reports·2026
Same author

A Catalog of the Pathogenic Variants in ABCG5 and ABCG8 and Clinical Features in Sitosterolemia.

Journal of atherosclerosis and thrombosis·2026
Same author

Ferroptosis susceptibility in primary coenzyme Q<sub>10</sub> deficiency: Cellular insights from patient fibroblasts and clinical course of six individuals.

Brain & development·2025

Related Experiment Video

Updated: Feb 14, 2026

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes
10:56

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes

Published on: September 15, 2018

8.5K

Guidance for Pediatric Familial Hypercholesterolemia 2017.

Mariko Harada-Shiba1, Takao Ohta2, Akira Ohtake3

  • 1Department of Molecular Innovation in Lipidology, National Cerebral and Cardiovascular Center Research Institute.

Journal of Atherosclerosis and Thrombosis
|February 9, 2018
PubMed
Summary

This consensus statement provides guidance for diagnosing and managing pediatric Familial Hypercholesterolemia (FH). Early intervention with lifestyle changes and pharmacotherapy, including statins, is crucial for improving outcomes and reducing cardiovascular disease risk in children with FH.

Keywords:
Diagnostic criteriaGuidanceHeterozygoteHomozygoteLDL apheresisLifestylePediatric familial hypercholesterolemiaPharmacological therapy

More Related Videos

Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure
15:18

Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure

Published on: July 30, 2009

18.7K
Guidelines for Elective Pediatric Fiberoptic Intubation
11:19

Guidelines for Elective Pediatric Fiberoptic Intubation

Published on: January 17, 2011

18.7K

Related Experiment Videos

Last Updated: Feb 14, 2026

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes
10:56

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes

Published on: September 15, 2018

8.5K
Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure
15:18

Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure

Published on: July 30, 2009

18.7K
Guidelines for Elective Pediatric Fiberoptic Intubation
11:19

Guidelines for Elective Pediatric Fiberoptic Intubation

Published on: January 17, 2011

18.7K

Area of Science:

  • Pediatric Cardiology
  • Genetics
  • Atherosclerosis Research

Background:

  • Familial Hypercholesterolemia (FH) is a common genetic disorder characterized by high LDL cholesterol levels from birth.
  • Early-onset atherosclerosis in FH patients necessitates timely diagnosis and treatment to mitigate long-term cardiovascular risks.
  • Current management strategies require updated guidance for pediatric populations.

Purpose of the Study:

  • To establish a consensus statement for the diagnosis and management of pediatric Familial Hypercholesterolemia (FH).
  • To provide updated guidance for the Japan Pediatric Society and Japan Atherosclerosis Society.
  • To improve the long-term prognosis of children diagnosed with FH.

Main Methods:

  • Consensus development by a Joint Working Group of the Japan Pediatric Society and Japan Atherosclerosis Society.
  • Review of diagnostic criteria for pediatric heterozygous FH (LDL-C ≥140 mg/dL, family history).
  • Recommendations for lifestyle modifications, pharmacotherapy (statins), and monitoring for homozygous FH.

Main Results:

  • Diagnostic criteria for pediatric heterozygous FH established.
  • Pharmacotherapy, primarily statins, recommended for children ≥10 years with persistent LDL-C >180 mg/dL.
  • LDL apheresis indicated for homozygous FH patients unresponsive to pharmacotherapy.

Conclusions:

  • Early diagnosis and intervention are critical for improving the prognosis of pediatric FH.
  • A stepwise approach involving lifestyle changes and pharmacotherapy is recommended.
  • Regular assessment and monitoring are essential for managing FH in children.