Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Spinal reflexes in chinoform-administered rats.

M Hino, H Ono, H Fukuda

    The Journal of Toxicological Sciences
    |May 1, 1986
    PubMed
    Summary

    Chinoform (CF) caused motor incoordination in rats but did not affect spinal reflexes or descending influences from the locus coeruleus (LC) and nucleus raphe magnus (NRM). Segmental spinal circuits remained functional despite CF-induced ataxia.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Continuous epidural infusion of bupivacaine and buprenorphine for postoperative pain relief].

    Masui. The Japanese journal of anesthesiology·1992
    Same author

    [Sevoflurane anesthesia for asthmatic patients: report of five cases].

    Masui. The Japanese journal of anesthesiology·1992
    Same author

    Occurrence of the nfxB type mutation in clinical isolates of Pseudomonas aeruginosa.

    Antimicrobial agents and chemotherapy·1992
    Same author

    Identification of the binding site of 55kDa tumor necrosis factor receptor by synthetic peptides.

    Biochemical and biophysical research communications·1992
    Same author

    Two reactions are simultaneously catalyzed by a single enzyme: the arginine-dependent simultaneous formation of two products, ethylene and succinate, from 2-oxoglutarate by an enzyme from Pseudomonas syringae.

    Biochemical and biophysical research communications·1992
    Same author

    Molecular cloning in Escherichia coli, expression, and nucleotide sequence of the gene for the ethylene-forming enzyme of Pseudomonas syringae pv. phaseolicola PK2.

    Biochemical and biophysical research communications·1992

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Toxicology

    Background:

    • Chinoform (CF) is known to cause neurotoxicity.
    • The effects of CF on spinal reflex pathways are not well understood.
    • Descending pathways from the locus coeruleus (LC) and nucleus raphe magnus (NRM) modulate spinal reflexes.

    Purpose of the Study:

    • To investigate the impact of chinoform (CF) on spinal reflexes.
    • To determine if CF affects descending modulatory influences from the LC and NRM on spinal reflexes.
    • To assess the functional integrity of spinal circuits despite CF-induced neurotoxicity.

    Main Methods:

    • Rats were administered chinoform (CF) intraperitoneally for two days.
    • Spinal reflex potentials were recorded from the L5 ventral root following L5 dorsal root stimulation.
    • Descending influences from the LC and NRM on spinal reflexes were tested via electrical stimulation.

    Main Results:

    • CF administration resulted in observed motor incoordination, including abnormal gait and hindlimb ataxia, and in some cases, death.
    • No significant differences were found in the amplitude or shape of spinal reflexes between control and CF-treated groups.
    • Descending influences from the LC and NRM on spinal reflexes remained unaffected by CF treatment.

    Conclusions:

    • Acute chinoform (CF) exposure causes significant motor deficits in rats.
    • Segmental spinal reflexes are not impaired by acute CF administration, even in the presence of neurotoxic effects.
    • Descending modulatory pathways from the LC and NRM maintain their function on spinal reflexes despite CF-induced motor incoordination.

    Related Experiment Videos