Related Experiment Video
Updated: Feb 14, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
39.5K
Validating a Selective S1P1 Receptor Modulator Syl930 for Psoriasis Treatment
Ming Ji1,2, Nina Xue1, Fangfang Lai1
1State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College.
Biological & Pharmaceutical Bulletin
|February 9, 2018
Summary
A new drug, Syl930, targeting sphingosine-1-phosphate (S1P) signaling, shows significant anti-proliferative and anti-inflammatory effects in animal models of psoriasis. This indicates Syl930
Area of Science:
- Dermatology
- Immunology
- Pharmacology
Background:
- Psoriasis is a chronic inflammatory skin condition.
- T-cell infiltration is a key factor, but mechanisms remain unclear.
- Sphingosine-1-phosphate (S1P) signaling regulates immune cell trafficking and is a potential therapeutic target.
Purpose of the Study:
- To evaluate a novel selective S1P1 modulator, Syl930, for psoriasis treatment.
- To assess Syl930's efficacy in various psoriasis animal models.
Main Methods:
- Oral administration of Syl930.
- Testing in four distinct psoriasis animal models, including sodium lauryl sulfate (SLS)-induced and propranolol-induced models.
- Assessment of skin thickening, cell proliferation, and epidermal/granular layer changes.
Main Results:
- Syl930 demonstrated potent anti-proliferative and anti-inflammatory effects.
- Reduced skin thickening, inhibited basal cell proliferation, and improved granular layer scales.
- Ameliorated key psoriasis hallmarks like parakeratosis and acanthosis in a guinea pig model.
Conclusions:
- Syl930 effectively reduces psoriasis-like pathology in preclinical models.
- The selective S1P1 modulator shows promise as a therapeutic agent for psoriasis.
- Further clinical investigation of Syl930 for psoriasis treatment is warranted.
Related Concept Videos
01:29Reliability and Validity
14.1K
Reliability and validity are two important considerations that must be made with any type of data collection. Reliability refers to the ability to consistently produce a given result. In the context of psychological research, this would mean that any instruments or tools used to collect data do so in consistent, reproducible ways.
14.1K
01:31Internal Receptors
74.8K
Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
74.8K
01:18Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
489
Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
489
01:23Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
527
Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
527
01:15Data Validation
2.4K
Method validation is a crucial process in analytical chemistry designed to confirm that a given method consistently produces reliable and high-quality results. This process is essential when a method is applied to different sample matrices or when procedural modifications are made, ensuring that the results meet acceptable standards across various applications.
Key parameters for method validation include:
Key parameters for method validation include:
2.4K
01:03Data Validation
7.0K
Data validation is an essential part of a comprehensive assessment. Validation is confirming or verifying and opening the door to gathering more assessment data as it clarifies vague or unclear data. The process of checking and verifying the collected information is called data validation. The primary purpose of data validation is to ensure data is as free from error, bias, and misinterpretation as possible.
Nursing assessment guides are generally based on holistic models rather than medical...
Nursing assessment guides are generally based on holistic models rather than medical...
7.0K