Related Experiment Video

Updated: Feb 14, 2026

Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology
06:19

Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology

Published on: May 31, 2024

1.7K

Adverse drug events in Chinese pediatric inpatients and associated risk factors: a retrospective review using the

Huan-Huan Ji1, Lin Song1, Jian-Wen Xiao2

  • 1Department of Pharmacy, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child development and Critical Disorders, Chongqing Key Laboratory of Pediatric, Children's Hospital of Chongqing Medical University, CHONGQING, 400014, China.

Scientific Reports
|February 9, 2018
PubMed

Insights

This study highlights that 12.7% of pediatric inpatients experienced adverse drug events (ADEs). A pediatric-focused Global Trigger Tool (GTT) effectively identified these events, aiding in harm reduction strategies.

Area of Science:

  • Pediatric pharmacology
  • Patient safety research
  • Health informatics

Background:

  • Adverse drug events (ADEs) pose significant risks to hospitalized children.
  • Effective methods are needed to identify and prevent ADEs in pediatric populations.
  • The Global Trigger Tool (GTT) is a validated method for retrospective harm assessment.

Purpose of the Study:

  • To evaluate the epidemiology and risk factors of ADEs in pediatric inpatients.
  • To assess the feasibility and utility of a pediatric-specific Global Trigger Tool (GTT) for ADE detection.
  • To identify patient characteristics associated with increased risk of ADEs.

Main Methods:

  • A three-stage retrospective chart review of 1800 pediatric inpatients (January 2013-December 2015).
  • Development and application of 31 pediatric-specific triggers based on existing literature.
  • Calculation of trigger positive predictive values (PPVs) and ADE detection rates.
  • Stepwise logistic regression analysis to identify risk factors for ADEs.

Main Results:

  • Out of 1746 analyzed patients, 221 (12.7%) experienced 247 ADEs.
  • The overall PPV of the pediatric-focused trigger tool was 13.3%.
  • The majority of ADEs were classified under categories E (82.6%), F (11.7%), and H (5.7%).
  • Increased drug counts, doses, and prior admissions were associated with higher ADE risk.

Conclusions:

  • The pediatric-focused GTT is a feasible and effective tool for detecting ADEs in hospitalized children.
  • Identifying patients with multiple medications, high doses, or frequent admissions is crucial for targeted ADE prevention.
  • This tool supports efforts to reduce harm from ADEs in pediatric care settings.

More Related Videos

In Vitro Rearing of Solitary Bees: A Tool for Assessing Larval Risk Factors08:50

In Vitro Rearing of Solitary Bees: A Tool for Assessing Larval Risk Factors

Published on: July 16, 2018

8.7K
Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies10:11

Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies

Published on: October 22, 2014

19.7K

Related Concept Videos

Drug Toxicity: Risk factors01:24

Drug Toxicity: Risk factors

Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
18
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.9K
Factors Affecting Protein-Drug Binding: Drug-Related Factors01:18

Factors Affecting Protein-Drug Binding: Drug-Related Factors

Drug binding to proteins is a complex phenomenon influenced by various drug-related factors, each playing a significant role in the interaction between drugs and proteins within the body.
One crucial factor in drug-protein binding is the drug's lipophilicity or its affinity for fat. More lipophilic drugs tend to have higher binding extents. For example, highly lipophilic drugs like cloxacillin exhibit substantial protein binding, with as much as 95% of the drug binding to proteins. In...
508
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
279
Global Climate Change01:50

Global Climate Change

Throughout its ~4.5 billion year history, the Earth has experienced periods of warming and cooling. However, the current drastic increase in global temperatures is well outside of the Earth’s cyclic norms, and evidence for human-caused global climate change is compelling. Paleoclimatology, the study of ancient climate conditions, provides ample evidence for human-caused global climate change by comparing recent conditions with those in the past.
29.1K
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
334