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Clinical trial registration: A practical perspective.
1Department of Anaesthesiology, VIMS, Ballari, Karnataka, India.
Indian Journal of Anaesthesia
|February 9, 2018
Summary
Clinical trial registration enhances transparency and quality in medical research. Mandated registration, guided by the World Health Organization, prevents substandard publications and resource waste.
Area of Science:
- Medical research ethics
- Clinical trial management
Background:
- Increasing clinical trials risk substandard publications and resource waste.
- Concerns exist regarding inadequate reporting and concealment of trial results.
- Lack of transparency erodes public trust in medicine.
Purpose of the Study:
- To review clinical trial registries and the registration process.
- To guide users on the Clinical Trials Registry of India (CTRI) and International Clinical Trials Registry Platform (ICTRP).
- To highlight the role of the International Committee of Medical Journal Editors in trial registration and publication.
Main Methods:
- Review of existing clinical trial registries and guidelines.
- Examination of the World Health Organization's International Clinical Trials Registry Platform (ICTRP) framework.
- Analysis of the Clinical Trials Registry of India (CTRI) registration and search functionalities.
Main Results:
- Clinical trial registration is mandated by regulatory bodies to streamline trials.
- Free registration sites like CTRI, based on ICTRP guidelines, are available.
- CTRI and ICTRP offer various search options for registered trials.
Conclusions:
- Mandatory clinical trial registration improves data quality and transparency.
- Utilizing registries like CTRI and ICTRP is crucial for ethical medical research.
- Publication of trial registration numbers is essential for scientific integrity.
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