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Related Concept Videos

Clinical Trials01:16

Clinical Trials

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
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Clinical Trials: Overview01:11

Clinical Trials: Overview

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
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Statistical Software for Data Analysis and Clinical Trials01:12

Statistical Software for Data Analysis and Clinical Trials

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Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
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Psychodynamic Perspectives on Personality01:27

Psychodynamic Perspectives on Personality

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The psychodynamic perspective in psychology asserts that most personality functions operate unconsciously, outside of awareness. This means that the motives and emotions driving behavior often remain hidden, automatically buried in the unconscious mind as a defense mechanism to shield us from psychological distress. According to this theory, the unconscious mind contains thoughts, memories, and emotions that are too disturbing to face directly.
Psychodynamic theorists argue that unconscious...
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Trial and Error and Algorithm01:12

Trial and Error and Algorithm

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A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
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In Silico Clinical Trials for Cardiovascular Disease
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Clinical trial registration: A practical perspective.

S Bala Bhaskar1

  • 1Department of Anaesthesiology, VIMS, Ballari, Karnataka, India.

Indian Journal of Anaesthesia
|February 9, 2018
PubMed
Summary
This summary is machine-generated.

Clinical trial registration enhances transparency and quality in medical research. Mandated registration, guided by the World Health Organization, prevents substandard publications and resource waste.

Keywords:
Indiamedical writingpublicationspublishingregistries

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Area of Science:

  • Medical research ethics
  • Clinical trial management

Background:

  • Increasing clinical trials risk substandard publications and resource waste.
  • Concerns exist regarding inadequate reporting and concealment of trial results.
  • Lack of transparency erodes public trust in medicine.

Purpose of the Study:

  • To review clinical trial registries and the registration process.
  • To guide users on the Clinical Trials Registry of India (CTRI) and International Clinical Trials Registry Platform (ICTRP).
  • To highlight the role of the International Committee of Medical Journal Editors in trial registration and publication.

Main Methods:

  • Review of existing clinical trial registries and guidelines.
  • Examination of the World Health Organization's International Clinical Trials Registry Platform (ICTRP) framework.
  • Analysis of the Clinical Trials Registry of India (CTRI) registration and search functionalities.

Main Results:

  • Clinical trial registration is mandated by regulatory bodies to streamline trials.
  • Free registration sites like CTRI, based on ICTRP guidelines, are available.
  • CTRI and ICTRP offer various search options for registered trials.

Conclusions:

  • Mandatory clinical trial registration improves data quality and transparency.
  • Utilizing registries like CTRI and ICTRP is crucial for ethical medical research.
  • Publication of trial registration numbers is essential for scientific integrity.