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Cytogenetic Abnormalities Found in Patients with Reproductive Problems
Mirela Mackic-Djurovic1, Sabaheta Hasic2, Emina Kiseljakovic2
1Center for Genetic, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Introduction:
One of the important causes of male infertility is aberration at the chromosomes.
Aim:
The main purpose of this study was to determine the frequency and types of chromosomal aberration in infertile/sterile men whose samples were analyzed in the Center for Cytogenetics of Faculty of Medicine University of Sarajevo in the last four years.
Methods:
A total of 353 infertile/sterile men, between the ages of 22-55 years, referred for cytogenetic analysis to the Center for Genetics of Faculty of Medicine during the period 2013-2016. Karyotyping was performed on peripheral blood lymphocytes by using the Giemsa trypsin banding (GTG) technique.
Results:
The structural and numerical chromosomal aberration in infertility/ sterility of men found with the incidence of 6% (20/353). Out of the 20 patients with abnormal cytogenetic diagnosis, structural chromosome abnormalities were observed in 17 (85%) patients and 3 (15%) with numerical aberrations. The type of aberrations mostly found were Robertsonian and reciprocal translocations (35%, 35%, respectively).
Conclusions:
The incidence of chromosomal abnormalities in infertile/sterile males suggests that the cytogenetics analysis is an important in male infertility, especially if it will be used for the purpose of assisted reproduction techniques.
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