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Study of Echocardiographic Changes After Kidney Transplantation in End-stage Renal Disease Patients
Hamidreza Omrani1, Alireza Rai2, Zahra Daraei1
1Nephrology and Urology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Insights
Kidney transplantation significantly improves cardiovascular health in end-stage renal disease (ESRD) patients. Echocardiographic findings show enhanced cardiac function 6 and 12 months post-transplant compared to pre-transplant status.
Area of Science:
- Nephrology
- Cardiology
- Transplantation Medicine
Background:
- Cardiovascular complications are the primary cause of death in end-stage renal disease (ESRD) patients.
- Evaluating the impact of kidney transplantation on cardiovascular status in ESRD is crucial.
Purpose of the Study:
- To assess the efficacy of kidney transplantation in improving cardiovascular status among ESRD patients.
- To analyze changes in cardiac function following kidney transplantation.
Main Methods:
- A cross-sectional study involving 181 ESRD patients undergoing kidney transplantation.
- Patients were followed for 6 and 12 months post-transplantation, with echocardiographic assessments.
- Inclusion criteria: ESRD, transplant recipients, reduced ejection fraction, hypertrophy, valve regurgitation. Exclusion criteria: transplant rejection, MI, resistant hypertension, addiction.
Main Results:
- The study included 181 patients (mean age 38.52, 54.7% male) with a mean dialysis duration of 3.74 years.
- Significant improvements in all echocardiographic findings were observed at 6 and 12 months post-transplantation compared to baseline.
- Cardiac function showed progressive improvement from 6 to 12 months post-transplantation.
Conclusions:
- Kidney transplantation demonstrates a positive impact on the cardiovascular status of ESRD patients.
- Transplantation effectively enhances cardiac function in this patient population.
Background:
Cardiovascular complications are the leading cause of mortality in end-stage renal disease (ESRD) patients. This study aimed to evaluate the efficacy of kidney transplantation on the cardiovascular status in ESRD patients.
Methods:
During 2012 to 2014 and in a cross-sectional study, 181 patients were randomly selected for this study. All patients were followed for periods of 6 and 12 months after kidney transplantation. The patients with ESRD and kidney transplant recipients; the patients with left ventricle ejection fraction<50%, left ventricular hypertrophy, mitral valve regurgitation and tricuspid valve regurgitation were included to study and the patients with kidney transplant rejection, myocardial infarction, high blood pressure with treatment-resistant, high blood pressure and addicted patients were censored.
Results:
one hundred and eighty-one patients had the mean age of 38.52 (range, 16-69 years) that 54.7% were men and the mean duration of dialysis was 3.74 years. There were significant differences after 6 and 12 months compared with before and also 6 months compared with 12 months from kidney transplantation for all echocardiographic findings. The echocardiographic findings improved after 12 months compared with 6 months and also these times compared with before kidney transplantation.
Conclusions:
The results of this study appeared that kidney transplantation had a positive effect on the cardiovascular status of patients with ESRD and improved the cardiac function of these patients.
