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Effects on Glycemic Control in Impaired Wound Healing in Spontaneously Diabetic Torii (SDT) Fatty Rats

Miyajima Katsuhiro1, Soon Hui Teoh1, Hideaki Yamashiro2

  • 1Department of Nutritional Science and Food Safety Faculty of Applied Biosciences, Tokyo University of Agriculture, Tokyo, Japan.

Medical Archives (Sarajevo, Bosnia and Herzegovina)
|February 9, 2018
PubMed
Abstract

Insights

Glycemic control significantly improves impaired wound healing in diabetic rats. This study highlights the effectiveness of managing blood sugar for diabetic wound treatment using a novel obese type 2 diabetes model.

Area of Science:

  • Endocrinology
  • Wound Healing Research
  • Diabetology

Background:

  • Impaired diabetic wound healing is a significant complication of diabetes.
  • The Spontaneously Diabetic Torii (SDT) fatty rat, an obese type 2 diabetes model, was used to study wound repair.
  • Understanding delayed wound healing in diabetes is crucial for developing effective treatments.

Purpose of the Study:

  • To evaluate the protective effect of glycemic control on impaired diabetic wound healing.
  • To investigate the efficacy of a sodium glucose co-transporter (SGLT) 2 inhibitor in improving wound repair in a diabetic rat model.
  • To assess the utility of the SDT fatty rat as a model for studying diabetic wound pathophysiology.

Main Methods:

  • Male SDT fatty rats (15 weeks old) received oral SGLT 2 inhibitor treatment for 3 weeks.
  • Wounds were induced in the rats 2 weeks after the SGLT 2 inhibitor treatment began.
  • Morphological and histological analyses were performed to examine wound healing progression.

Main Results:

  • SDT fatty rats exhibited delayed wound healing compared to normal rats.
  • Glycemic control, achieved with SGLT 2 inhibitor treatment, improved impaired wound healing.
  • Histological examination revealed severe inflammation, bacterial masses, and delayed tissue regeneration in untreated SDT rats, which were ameliorated by the SGLT 2 inhibitor.

Conclusions:

  • Glycemic control is an effective therapeutic strategy for diabetic wounds.
  • The SDT fatty rat model is valuable for investigating the pathophysiology of impaired diabetic wound healing.
  • SGLT 2 inhibitor treatment shows promise in enhancing diabetic wound repair.
Keywords:
blood glucosediabetic complicationratsodium-glucose transporter 2wound healing

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