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Aging and the Krüppel-like factors.
Paishiun N Hsieh1,2, David R Sweet1,2, Liyan Fan1,2
1Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
Trends in Cell & Molecular Biology
|February 9, 2018
Summary
Mammalian Krüppel-like factors (KLFs), transcription factors, are increasingly recognized for their role in aging. This review explores their functions in aging processes and age-related diseases.
Area of Science:
- Molecular Biology
- Genetics
- Gerontology
Background:
- Mammalian Krüppel-like factors (KLFs) are a diverse family of transcription factors.
- These factors exhibit varied expression patterns and cellular functions.
- Their established roles in mammalian physiology are expanding to include aging.
Purpose of the Study:
- To review current knowledge on Krüppel-like factors (KLFs).
- To focus on the specific roles of KLFs in aging processes.
- To examine the involvement of KLFs in age-associated diseases.
Main Methods:
- Literature review of scientific publications.
- Analysis of studies on KLF expression and function.
- Synthesis of data on KLFs in aging and disease models.
Main Results:
- KLFs play significant roles in fundamental aging processes.
- Specific KLFs are implicated in the development of age-related diseases.
- Understanding KLF functions offers insights into aging mechanisms.
Conclusions:
- Krüppel-like factors are critical regulators of aging.
- Targeting KLFs may offer therapeutic strategies for age-associated conditions.
- Further research into KLFs is essential for advancing gerontology.
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