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Increased risk of venous thromboembolism associated with polymyositis and dermatomyositis: a meta-analysis

Yanqing Li1, Peihong Wang2, Lei Li3

  • 1Department of Pharmacy Intravenous Admixture Services, Affiliated Hospital of Weifang Medical University, Weifang.

Therapeutics and Clinical Risk Management
|February 9, 2018
PubMed
Abstract

Insights

Patients with inflammatory myositis, including polymyositis (PM) and dermatomyositis (DM), face a significantly higher risk of developing venous thromboembolism (VTE). This meta-analysis confirms a strong association between these conditions and VTE development.

Area of Science:

  • Rheumatology
  • Cardiovascular Medicine
  • Epidemiology

Background:

  • Polymyositis and dermatomyositis (PM/DM) are inflammatory myopathies.
  • Previous research on the association between PM/DM and venous thromboembolism (VTE) risk has produced conflicting results.
  • A precise estimation of this association is needed.

Purpose of the Study:

  • To conduct a meta-analysis of available publications to precisely estimate the association between polymyositis/dermatomyositis and the risk of venous thromboembolism.
  • To provide robust evidence regarding the VTE risk in patients with inflammatory myositis.

Main Methods:

  • A comprehensive literature search was performed across PubMed, Embase, and the Cochrane Library.
  • Two independent investigators screened studies for eligibility.
  • Pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated to quantify the association. Stratified and sensitivity analyses were conducted.

Main Results:

  • The meta-analysis included six studies with a total of 9,045 patients.
  • Inflammatory myositis was significantly associated with an increased risk of VTE (OR = 4.31).
  • Both polymyositis (OR = 6.87) and dermatomyositis (OR = 11.59) showed elevated VTE risks, as did deep vein thrombosis (DVT) and pulmonary embolism (PE).

Conclusions:

  • This meta-analysis provides strong evidence linking inflammatory myositis to a substantially increased risk of VTE.
  • Patients diagnosed with polymyositis or dermatomyositis should be monitored for VTE development.
  • Further research may explore underlying mechanisms and preventative strategies.
Keywords:
deep venous thrombosisdermatomyositispolymyositispulmonary embolismvenous thromboembolism

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