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Updated: Feb 14, 2026
07:34
Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies
Published on: April 11, 2012
20.1K
Raising concerns about the Sepsis-3 definitions.
Massimo Sartelli1, Yoram Kluger2, Luca Ansaloni3
1Department of Surgery, Macerata Hospital, Macerata, Italy.
World Journal of Emergency Surgery : WJES
|February 9, 2018
Summary
The Global Alliance for Infections in Surgery acknowledges the Sepsis-3 definitions as progress but raises concerns about their practical application nearly a year after publication. Further evaluation is needed for optimal sepsis management.
Area of Science:
- Infectious Diseases
- Critical Care Medicine
- Surgical Infections
Background:
- The Sepsis-3 definitions represent a significant advancement in understanding sepsis.
- The Global Alliance for Infections in Surgery (GAIS) supports the Sepsis-3 definitions.
Purpose of the Study:
- To express concerns regarding the clinical utility and application of the Sepsis-3 definitions.
- To highlight areas needing further clarification and validation of the Sepsis-3 criteria.
Main Methods:
- Review of the Sepsis-3 definitions and their implications.
- Discussion of practical challenges encountered in applying the new definitions.
Main Results:
- The Sepsis-3 definitions are a step forward in sepsis understanding.
- GAIS has identified several concerns regarding the use of Sepsis-3 in clinical practice.
Conclusions:
- While Sepsis-3 is an important evolution, its widespread application requires addressing identified concerns.
- Further dialogue and potential refinements are necessary to ensure the definitions effectively guide sepsis diagnosis and treatment.
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