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The Organoid Reconstitution Assay ORA for the Functional Analysis of Intestinal Stem and Niche Cells
Published on: November 20, 2017
3D modeling of cancer stem cell niche
Jun He1, Li Xiong1, Qinglong Li1
1Department of General Surgery, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Abstract:
Cancer stem cells reside in a distinct microenvironment called niche. The reciprocal interactions between cancer stem cells and niche contribute to the maintenance and enrichment of cancer stem cells. In order to simulate the interactions between cancer stem cells and niche, three-dimensional models have been developed. These in vitro culture systems recapitulate the spatial dimension, cellular heterogeneity, and the molecular networks of the tumor microenvironment and show great promise in elucidating the pathophysiology of cancer stem cells and designing more clinically relavant treatment modalites.
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