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Troponin through the looking-glass: emerging roles beyond regulation of striated muscle contraction

Jamie R Johnston1, P Bryant Chase2, Jose Renato Pinto1

  • 1Department of Biomedical Sciences, The Florida State University College of Medicine, Tallahassee, FL, 32306-4300, USA.

Oncotarget
|February 9, 2018
PubMed

Insights

Troponin, a muscle contraction protein, has new roles in cancer, heart disease, and aging. Research reveals its non-canonical functions beyond the sarcomere, impacting various cellular processes.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cellular Biology

Background:

  • Troponin is a key regulator of striated muscle contraction.
  • Emerging evidence suggests troponin has functions beyond its canonical role in muscle contraction.
  • Aberrant troponin expression is linked to diseases like cancer and cardiomyopathy, and to skeletal muscle aging.

Purpose of the Study:

  • To explore the non-canonical roles of troponin.
  • To investigate aberrant expression patterns of troponin outside the sarcomeric environment.
  • To analyze troponin's involvement in various subcellular compartments and cellular processes.

Main Methods:

  • Bioinformatics tools and online databases were utilized.
  • Pathway analysis was performed.
  • Subcellular localization, protein-protein, and protein-DNA interactions were analyzed.

Main Results:

  • Troponin exhibits non-canonical roles and aberrant expression patterns.
  • Analysis supports troponin's presence and function in multiple subcellular compartments.
  • Evidence suggests troponin's involvement in pathways beyond muscle contraction.

Conclusions:

  • Troponin's function extends beyond sarcomeric regulation of muscle contraction.
  • Troponin plays roles in diverse cellular processes, impacting cancer, cardiomyopathy, and aging.
  • This challenges the traditional view of troponin and opens new avenues for disease research.
Keywords:
cancercardiomyopathynucleusstriated muscletroponin

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