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Real Time Detection of In Vitro Tumor Cell Apoptosis Induced by CD8+ T Cells to Study Immune Suppressive Functions of Tumor-infiltrating Myeloid Cells
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PML: Regulation and multifaceted function beyond tumor suppression

Kuo-Sheng Hsu1,2, Hung-Ying Kao1,3

  • 11Department of Biochemistry, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 USA.

Cell & Bioscience
|February 9, 2018
PubMed

Insights

Promyelocytic leukemia protein (PML) is a tumor suppressor involved in apoptosis and cell cycle regulation. New findings reveal its diverse roles beyond cancer, including stem cell renewal and metabolism.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Promyelocytic leukemia protein (PML) identified as a fusion partner in acute promyelocytic leukemia.
  • PML exhibits tumor-suppressing activity by regulating apoptosis, cell cycle, senescence, and DNA damage responses.
  • PML localizes to nuclear bodies (NBs) and other cellular compartments, with dysregulation impacting cellular processes.

Purpose of the Study:

  • To review the known regulation and function of PML.
  • To incorporate recent findings on PML's diverse biological roles.

Main Methods:

  • Literature review of existing studies on PML.
  • Synthesis of new research findings on PML function.

Main Results:

  • PML's established role in tumor suppression through regulation of key cellular processes.
  • Emerging evidence highlights PML's involvement in stem cell renewal, metabolism, inflammation, neural function, and angiogenesis.

Conclusions:

  • PML is a multifaceted protein with critical roles in both tumor suppression and normal physiological processes.
  • Further research into PML's diverse functions may uncover new therapeutic targets.
Keywords:
AngiogenesisChemotherapy resistanceGene expressionInflammatory responsesMammary developmentMetabolismNeural functionPMLProtein modificationProteolysisStem cell and cancer stem cell renewal

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