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Updated: Feb 14, 2026

Modeling Charcot-Marie-Tooth Disease In Vitro by Transfecting Mouse Primary Motoneurons
Published on: January 7, 2019
Operative treatment algorithm for foot deformities in Charcot-Marie-Tooth disease
1Foot and Ankle Reconstruction Unit, St Maartenskliniek, Postbox 9011, 6500 GM, Nijmegen, The Netherlands. j.louwerens@maartenskliniek.nl.
Abstract:
The present article presents a short summary concerning the pathomechanisms and clinical presentation of foot deformities in Charcot-Marie-Tooth syndrome. Furthermore, a classification system is introduced and based on a recently performed review of the literature an operative treatment algorithm is provided. The operative technique of the following surgical procedures is described in more detail: 1. dorsiflexion osteotomy at the base of the 1st metatarsus, 2. dorsiflexion osteotomy at the base of a lesser metatarsal bone, 3. claw hallux correction including fusion of the first phalangeal joint, 4. claw toe correction, 5. transfer of extensor digitorum longus tendons to the peroneal tendons and finally 6. tibialis posterior tendon transfer to the dorsiflexors of the foot.
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