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[Decrease of the serum level of selenium in chronic alcoholics with or without dilated cardiomyopathy].

T Thuong, P Auzépy, M Blondeau

    Presse Medicale (Paris, France : 1983)
    |April 12, 1986
    PubMed
    Summary
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    Serum selenium levels are significantly lower in patients with chronic alcoholism, malnutrition, and cardiomyopathy. This suggests that selenium deficiency is linked to these conditions, especially congestive cardiomyopathy.

    Area of Science:

    • Biochemistry
    • Clinical Nutrition
    • Cardiology

    Background:

    • Selenium is an essential trace element crucial for various physiological functions.
    • Low selenium levels have been implicated in several chronic diseases, including cardiovascular conditions.
    • Nutritional status, particularly in patients with alcoholism, can significantly impact selenium bioavailability.

    Purpose of the Study:

    • To investigate serum selenium concentrations in patients with chronic alcoholism, malnutrition, and congestive cardiomyopathy.
    • To determine the relationship between selenium levels and these clinical conditions.
    • To assess the potential role of selenium deficiency in the pathogenesis of congestive cardiomyopathy.

    Main Methods:

    • Serum selenium concentrations were quantified using electrothermal atomic absorption spectrophotometry.

    Related Experiment Videos

  • A cohort of 31 healthy controls and 101 patients (chronic alcoholics, malnourished patients, and patients with cardiomyopathy) were analyzed.
  • Statistical comparisons were made between the control group and patient subgroups.

    • Main Results:

    • All patient groups exhibited statistically significant lower mean serum selenium concentrations compared to controls (P < 0.001).
    • No significant differences in serum selenium were observed between patients with cardiomyopathy and those with malnutrition.
    • Both chronic alcoholism and malnutrition were associated with reduced blood selenium levels.

    Conclusions:

    • Chronic alcoholism and malnutrition are linked to decreased serum selenium concentrations.
    • The observed decrease in serum selenium in both alcoholic and non-alcoholic patients with cardiomyopathy suggests an association with selenium deficiency.
    • Congestive cardiomyopathy patients require evaluation for both alcoholism and nutritional status, considering potential selenium deficiency.